{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:02:48Z","timestamp":1792638168598,"version":"4.5.0"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5904","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2008,11,14]]},"abstract":"<jats:p>\n                    Although in vitro observations suggest that cross-presentation of antigens is mediated primarily by CD8\u03b1\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells, in vivo analysis has been hampered by the lack of systems that selectively eliminate this cell lineage. We show that deletion of the transcription factor\n                    <jats:italic>Batf3<\/jats:italic>\n                    ablated development of CD8\u03b1\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells, allowing us to examine their role in immunity in vivo. Dendritic cells from\n                    <jats:italic>Batf3<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice were defective in cross-presentation, and\n                    <jats:italic>Batf3<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice lacked virus-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses to West Nile virus. Importantly, rejection of highly immunogenic syngeneic tumors was impaired in\n                    <jats:italic>Batf3<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice. These results suggest an important role for CD8\u03b1\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells and cross-presentation in responses to viruses and in tumor rejection.\n                  <\/jats:p>","DOI":"10.1126\/science.1164206","type":"journal-article","created":{"date-parts":[[2008,11,13]],"date-time":"2008-11-13T16:47:59Z","timestamp":1226594879000},"page":"1097-1100","source":"Crossref","is-referenced-by-count":2044,"title":["<i>Batf3<\/i>\n                    Deficiency Reveals a Critical Role for CD8\u03b1\n                    <sup>+<\/sup>\n                    Dendritic Cells in Cytotoxic T Cell Immunity"],"prefix":"10.1126","volume":"322","author":[{"given":"Kai","family":"Hildner","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA."},{"name":"Howard Hughes Medical Institute, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA."},{"name":"Departments of Medicine and Molecular Microbiology, 660 South Euclid Avenue, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Edelson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA."},{"name":"Howard Hughes Medical Institute, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA."},{"name":"Departments of Medicine and Molecular Microbiology, 660 South Euclid Avenue, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney E.","family":"Purtha","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA."},{"name":"Howard 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R.","family":"Unanue","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA."},{"name":"Howard Hughes Medical Institute, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA."},{"name":"Departments of Medicine and Molecular Microbiology, 660 South Euclid Avenue, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Diamond","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA."},{"name":"Howard Hughes Medical Institute, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA."},{"name":"Departments of Medicine and Molecular Microbiology, 660 South Euclid Avenue, St. Louis, MO 63110, 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