{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:20:52Z","timestamp":1792441252036,"version":"4.5.0"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5909","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2008,12,19]]},"abstract":"<jats:p>\n                    The host tissue microenvironment influences malignant cell proliferation and metastasis, but little is known about how tumor-induced changes in the microenvironment affect benign cellular ecosystems. Applying dynamic in vivo imaging to a mouse model, we show that leukemic cell growth disrupts normal hematopoietic progenitor cell (HPC) bone marrow niches and creates abnormal microenvironments that sequester transplanted human CD34\n                    <jats:sup>+<\/jats:sup>\n                    (HPC-enriched) cells. CD34\n                    <jats:sup>+<\/jats:sup>\n                    cells in leukemic mice declined in number over time and failed to mobilize into the peripheral circulation in response to cytokine stimulation. Neutralization of stem cell factor (SCF) secreted by leukemic cells inhibited CD34\n                    <jats:sup>+<\/jats:sup>\n                    cell migration into malignant niches, normalized CD34\n                    <jats:sup>+<\/jats:sup>\n                    cell numbers, and restored CD34\n                    <jats:sup>+<\/jats:sup>\n                    cell mobilization in leukemic mice. These data suggest that the tumor microenvironment causes HPC dysfunction by usurping normal HPC niches and that therapeutic inhibition of HPC interaction with tumor niches may help maintain normal progenitor cell function in the setting of malignancy.\n                  <\/jats:p>","DOI":"10.1126\/science.1164390","type":"journal-article","created":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T17:48:43Z","timestamp":1229622523000},"page":"1861-1865","source":"Crossref","is-referenced-by-count":540,"title":["Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells"],"prefix":"10.1126","volume":"322","author":[{"given":"Angela","family":"Colmone","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology, The University of Chicago, 5841 South Maryland Avenue MC 2115, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Amorim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology, The University of Chicago, 5841 South Maryland Avenue MC 2115, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Pontier","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology, The University of Chicago, 5841 South Maryland Avenue MC 2115, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology, The University of Chicago, 5841 South Maryland Avenue MC 2115, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Jablonski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology, The University of Chicago, 5841 South Maryland Avenue MC 2115, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy A.","family":"Sipkins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology, The University of Chicago, 5841 South Maryland Avenue MC 2115, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5469-5"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00025.2005"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28568"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02041"},{"key":"e_1_3_1_6_2","first-page":"1232","volume":"106","year":"2005","unstructured":"S. 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Nilssonet al., Blood106, 1232 (2005).","journal-title":"Blood"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.07.004"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02040"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.026"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03703"},{"key":"e_1_3_1_11_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5403.845"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402684"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282f29012"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1075"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10520"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21043"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705908"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.10.2547"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.10.4100.bloodjournal87104100"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2003.08.015"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(99)00076-X"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2006.15.755"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603063"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00569.x"},{"key":"e_1_3_1_26_2","first-page":"851","volume":"29","year":"2006","unstructured":"G. Belloneet al., Int. J. Oncol.29, 851 (2006).","journal-title":"Int. J. Oncol."},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0666"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(03)00184-X"},{"key":"e_1_3_1_29_2","unstructured":"We thank A. Chenn K. Cohen L. Godley and R. Salgia for critical discussions and reading of the manuscript; A. Chenn for assistance with retroviral cell transduction; A. Wickrema for help with CD34 + purification; V. Bindokas for imaging expertise; and S. Gurbuxani for assistance with histopathology interpretation. Supported by a grant from the Illinois Regenerative Medicine Institute (IRMI) an NIH (National Cancer Institute) K08 award (5K08CA112126-02) and an NIH Director's DP2 award (1DP2OD002160-01). A patent application related to this work has been filed by the University of Chicago."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1164390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:28:59Z","timestamp":1704860939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1164390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,19]]},"references-count":28,"journal-issue":{"issue":"5909","published-print":{"date-parts":[[2008,12,19]]}},"alternative-id":["10.1126\/science.1164390"],"URL":"https:\/\/doi.org\/10.1126\/science.1164390","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1145182.602330","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1145182.612952","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,19]]}}}