{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:38:41Z","timestamp":1791315521369,"version":"4.3.1"},"reference-count":33,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5965","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,1,29]]},"abstract":"<jats:title>Gut Check<\/jats:title>\n                  <jats:p>\n                    The gastrointestinal (GI) tract is particularly sensitive to damage by ionizing radiation. Despite decades of study, fundamental questions such as which cells and which molecular mechanisms mediate this GI damage remain a source of great controversy. Studying a series of genetically manipulated mice,\n                    <jats:bold>\n                      Kirsch\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"593\" related-article-type=\"in-this-issue\" vol=\"327\" xlink:href=\"10.1126\/science.1166202\">593<\/jats:related-article>\n                    , published online 17 December) conclude that GI epithelial cells, rather than endothelial cells, are the critical cellular targets of radiation damage and that apoptosis (a well-studied mechanism of cell death) is not a major contributor to the damage. Rather, an alternative cell-death pathway whose activity is inhibited by the tumor suppressor protein p53 appears to mediate GI damage. Further insights into this pathway may assist the development of medical counter-measures for preventing and treating radiation-induced tissue damage.\n                  <\/jats:p>","DOI":"10.1126\/science.1166202","type":"journal-article","created":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T02:26:43Z","timestamp":1261103203000},"page":"593-596","source":"Crossref","is-referenced-by-count":223,"title":["p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis"],"prefix":"10.1126","volume":"327","author":[{"given":"David G.","family":"Kirsch","sequence":"first","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA."},{"name":"Departments of Radiation Oncology and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27708, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Santiago","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"di Tomaso","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27708, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Shiun","family":"Hou","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talya","family":"Dayton","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B.","family":"Jeffords","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27708, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Sodha","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim L.","family":"Mercer","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhianna","family":"Cohen","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Dana Farber Cancer Institute, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley J.","family":"Korsmeyer","sequence":"additional","affiliation":[{"name":"Dana Farber Cancer Institute, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick T.","family":"Bronson","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine and Veterinary Medicine, North Grafton, MA 05136, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla F.","family":"Kim","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Haigis","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Jacks","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra000365"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553007414550431"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90108-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2307\/3577353"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.12.001"},{"key":"e_1_3_2_7_2","first-page":"614","article-title":"The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.","volume":"54","author":"Merritt A. J.","year":"1994","unstructured":"Merritt A. J., et al.., The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 54, 614 (1994).8306319","journal-title":"Cancer Res."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/269518a0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00244-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090072"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.03.009"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1060191"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80091-4"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082504"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.11.043"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207494"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201126"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553008214551601"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2307\/3573763"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553009014550431"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00399-X"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20042"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.6.741"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504783102"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00136-2"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-162941"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504830102"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401724"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf595"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154986"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5434.1733"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05077"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1223"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1667\/RR3597.1"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1166202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:03:40Z","timestamp":1704859420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1166202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,29]]},"references-count":33,"journal-issue":{"issue":"5965","published-print":{"date-parts":[[2010,1,29]]}},"alternative-id":["10.1126\/science.1166202"],"URL":"https:\/\/doi.org\/10.1126\/science.1166202","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1345979.817080","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,29]]}}}