{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:40:25Z","timestamp":1791031225849,"version":"4.1.0"},"reference-count":26,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5915","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,2,6]]},"abstract":"<jats:p>\n                    Platelets play a critical role in the pathogenesis of malarial infections by encouraging the sequestration of infected red blood cells within the cerebral vasculature. But platelets also have well-established roles in innate protection against microbial infections. We found that purified human platelets killed\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    parasites cultured in red blood cells. Inhibition of platelet function by aspirin and other platelet inhibitors abrogated the lethal effect human platelets exert on\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    parasites. Likewise, platelet-deficient and aspirin-treated mice were more susceptible to death during erythrocytic infection with\n                    <jats:italic>Plasmodium chabaudi<\/jats:italic>\n                    . Both mouse and human platelets bind malarial-infected red cells and kill the parasite within. These results indicate a protective function for platelets in the early stages of erythrocytic infection distinct from their role in cerebral malaria.\n                  <\/jats:p>","DOI":"10.1126\/science.1166296","type":"journal-article","created":{"date-parts":[[2009,2,6]],"date-time":"2009-02-06T23:02:12Z","timestamp":1233961332000},"page":"797-800","source":"Crossref","is-referenced-by-count":254,"title":["Platelets Kill Intraerythrocytic Malarial Parasites and Mediate Survival to Infection"],"prefix":"10.1126","volume":"323","author":[{"given":"Brendan J.","family":"McMorran","sequence":"first","affiliation":[{"name":"The Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia."},{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Parkville, Victoria 3050, Australia."},{"name":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikki M.","family":"Marshall","sequence":"additional","affiliation":[{"name":"The Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia."},{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Parkville, Victoria 3050, Australia."},{"name":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"de Graaf","sequence":"additional","affiliation":[{"name":"The Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia."},{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Parkville, Victoria 3050, Australia."},{"name":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Drysdale","sequence":"additional","affiliation":[{"name":"The Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia."},{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Parkville, Victoria 3050, Australia."},{"name":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriam","family":"Shabbar","sequence":"additional","affiliation":[{"name":"The Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia."},{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Parkville, Victoria 3050, Australia."},{"name":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon K.","family":"Smyth","sequence":"additional","affiliation":[{"name":"The Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia."},{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Parkville, Victoria 3050, Australia."},{"name":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E.","family":"Corbin","sequence":"additional","affiliation":[{"name":"The Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia."},{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Parkville, Victoria 3050, Australia."},{"name":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren S.","family":"Alexander","sequence":"additional","affiliation":[{"name":"The Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia."},{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Parkville, Victoria 3050, Australia."},{"name":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Foote","sequence":"additional","affiliation":[{"name":"The Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia."},{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Parkville, Victoria 3050, Australia."},{"name":"Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1462-5822.2005.00524.x","volume":"7","year":"2005","unstructured":"G. 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Jackson for advice; R. Anders for providing the P. falciparum parasites; and C. Flowers for manuscript preparation. Funding support was from the National Health and Medical Research Council of Australia (Program Grants 490037 and 461219) Australian Cancer Research Foundation and Howard Hughes Medical Institute. Statistical Analysis. P values were calculated by means of two-tailed t tests except where specifically mentioned. Ethics approval for animal experiments was received from the Royal Melbourne Hospital Melbourne Australia (2002.053) and University of Tasmania (A0008702). Ethics approval for the platelet donations was received from Human Research Ethics Committee (Tasmania) Network (H0009004)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1166296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:31:01Z","timestamp":1704861061000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1166296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,6]]},"references-count":26,"journal-issue":{"issue":"5915","published-print":{"date-parts":[[2009,2,6]]}},"alternative-id":["10.1126\/science.1166296"],"URL":"https:\/\/doi.org\/10.1126\/science.1166296","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1157040.617127","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,6]]}}}