{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:52:19Z","timestamp":1790981539532,"version":"4.1.0"},"reference-count":21,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5912","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,1,16]]},"abstract":"<jats:p>Retroviruses have the potential to acquire host cell\u2013derived genetic material during reverse transcription and can integrate into the genomes of larger, more complex DNA viruses. In contrast, RNA viruses were believed not to integrate into the host's genome under any circumstances. We found that illegitimate recombination between an exogenous nonretroviral RNA virus, lymphocytic choriomeningitis virus, and the endogenous intracisternal A-type particle (IAP) retrotransposon occurred and led to reverse transcription of exogenous viral RNA. The resulting complementary DNA was integrated into the host's genome with an IAP element. Thus, RNA viruses should be closely scrutinized for any capacity to interact with endogenous retroviral elements before their approval for therapeutic use in humans.<\/jats:p>","DOI":"10.1126\/science.1167375","type":"journal-article","created":{"date-parts":[[2009,1,15]],"date-time":"2009-01-15T17:25:48Z","timestamp":1232040348000},"page":"393-396","source":"Crossref","is-referenced-by-count":130,"title":["Recombination of Retrotransposon and Exogenous RNA Virus Results in Nonretroviral cDNA Integration"],"prefix":"10.1126","volume":"323","author":[{"given":"Markus B.","family":"Geuking","sequence":"first","affiliation":[{"name":"Institute of Experimental Immunology, University Hospital Zu\u0308rich, Schmelzbergstrasse 12, 8091 Zu\u0308rich, Switzerland."},{"name":"CNRS Unite\u0301 Mixte de Recherche 8122, Unite\u0301 des Re\u0301trovirus Endoge\u0300nes et Ele\u0301ments Re\u0301troi\u0308des des Eucaryotes Supe\u0301rieurs, Institut Gustave Roussy, 94805 Villejuif Cedex and Universite\u0301 Paris-Sud 91405 Orsay, France."},{"name":"University of Pittsburgh Cancer Institute, Hillman Cancer Center, Room 1.46, Pittsburgh, PA 15232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, University Hospital Zu\u0308rich, Schmelzbergstrasse 12, 8091 Zu\u0308rich, Switzerland."},{"name":"CNRS Unite\u0301 Mixte de Recherche 8122, Unite\u0301 des Re\u0301trovirus Endoge\u0300nes et Ele\u0301ments Re\u0301troi\u0308des des Eucaryotes Supe\u0301rieurs, Institut Gustave Roussy, 94805 Villejuif Cedex and Universite\u0301 Paris-Sud 91405 Orsay, France."},{"name":"University of Pittsburgh Cancer Institute, Hillman Cancer Center, Room 1.46, Pittsburgh, PA 15232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Dewannieux","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, 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