{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:21:51Z","timestamp":1791274911089,"version":"4.1.0"},"reference-count":20,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5935","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,6,26]]},"abstract":"<jats:title>BDNF and Drug Dependence<\/jats:title>\n                  <jats:p>\n                    Brain-derived neurotrophic factor (BDNF) is a growth factor involved in neuronal plasticity that is expressed after chronic administration of drugs of abuse and may play a crucial role in chronic opiate effects.\n                    <jats:bold>\n                      Vargas-Perez\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1732\" related-article-type=\"in-this-issue\" vol=\"324\" xlink:href=\"10.1126\/science.1168501\">1732<\/jats:related-article>\n                    , published online 28 May) found that BDNF was directly involved in the switching mechanism in the ventral tegmental area, from an opiate-na\u00efve, dopamine-independent drug reward substrate to an opiate-dependent, dopamine-dependent motivational substrate. In the ventral tegmental area, BDNF changed the action of GABA-A receptors from inhibitory to excitatory. This change led to behavioral changes that defined a neurobiological boundary between the acute phase of drug-taking and addiction.\n                  <\/jats:p>","DOI":"10.1126\/science.1168501","type":"journal-article","created":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T21:50:05Z","timestamp":1243547405000},"page":"1732-1734","source":"Crossref","is-referenced-by-count":156,"title":["Ventral Tegmental Area BDNF Induces an Opiate-Dependent\u2013Like Reward State in Na\u00efve Rats"],"prefix":"10.1126","volume":"324","author":[{"given":"Hector","family":"Vargas-Perez","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Ting-A-Kee","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine H.","family":"Walton","sequence":"additional","affiliation":[{"name":"Department of Psychology, Brigham Young University, Provo, UT 84602, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Micah","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Psychology, Brigham Young University, Provo, UT 84602, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozita","family":"Razavi","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Clarke","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Rose","family":"Bufalino","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Psychology, Brigham Young University, Provo, UT 84602, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Steffensen","sequence":"additional","affiliation":[{"name":"Department of Psychology, Brigham Young University, Provo, UT 84602, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"van der Kooy","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada."},{"name":"Institute of Medical Science, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2001.01458.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1182"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00327-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200209011"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04223"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:5:1:069"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990118)403:3<295::AID-CNE2>3.0.CO;2-L"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-01-00335.1994"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-10-04110.1999"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5124-03.2004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.29.051605.113009"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.106.2.351"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02918.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05599.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03665.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02581-1"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3104-06.2007"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00742.2003"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00099-X"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.05.035"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1168501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:03:02Z","timestamp":1704859382000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1168501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,26]]},"references-count":20,"journal-issue":{"issue":"5935","published-print":{"date-parts":[[2009,6,26]]}},"alternative-id":["10.1126\/science.1168501"],"URL":"https:\/\/doi.org\/10.1126\/science.1168501","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1162461.623556","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1162461.623979","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,26]]}}}