{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:20:30Z","timestamp":1791724830604,"version":"4.3.4"},"reference-count":14,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5923","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,4,3]]},"abstract":"<jats:p>\n                    Plants possess inducible systemic defense responses when locally infected by pathogens. Bacterial infection results in the increased accumulation of the mobile metabolite azelaic acid, a nine-carbon dicarboxylic acid, in the vascular sap of\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    that confers local and systemic resistance against the pathogen\n                    <jats:italic>Pseudomonas syringae<\/jats:italic>\n                    . Azelaic acid primes plants to accumulate salicylic acid (SA), a known defense signal, upon infection. Mutation of the\n                    <jats:italic>AZELAIC ACID INDUCED 1 (AZI1)<\/jats:italic>\n                    gene, which is induced by azelaic acid, results in the specific loss of systemic immunity triggered by pathogen or azelaic acid and of the priming of SA induction in plants. Furthermore, the predicted secreted protein AZI1 is also important for generating vascular sap that confers disease resistance. Thus, azelaic acid and AZI1 are components of plant systemic immunity involved in priming defenses.\n                  <\/jats:p>","DOI":"10.1126\/science.1170025","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T17:36:39Z","timestamp":1238693799000},"page":"89-91","source":"Crossref","is-referenced-by-count":801,"title":["Priming in Systemic Plant Immunity"],"prefix":"10.1126","volume":"324","author":[{"given":"Ho Won","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and Cell Biology, The University of Chicago, 1103 East 57th Street EBC410, Chicago, IL 60637, USA."},{"name":"Oak Ridge National Laboratory, Environmental Sciences Division, Oak Ridge, TN 37831\u20136341, USA."},{"name":"Department of Plant Biology, Microbial and Plant Genomics Institute, University of Minnesota, 1500 Gortner Avenue, St. Paul, MN 55108, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Tschaplinski","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Cell Biology, The University of Chicago, 1103 East 57th Street EBC410, Chicago, IL 60637, USA."},{"name":"Oak Ridge National Laboratory, Environmental Sciences Division, Oak Ridge, TN 37831\u20136341, USA."},{"name":"Department of Plant Biology, Microbial and Plant Genomics Institute, University of Minnesota, 1500 Gortner Avenue, St. Paul, MN 55108, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Cell Biology, The University of Chicago, 1103 East 57th Street EBC410, Chicago, IL 60637, USA."},{"name":"Oak Ridge National Laboratory, Environmental Sciences Division, Oak Ridge, TN 37831\u20136341, USA."},{"name":"Department of Plant Biology, Microbial and Plant Genomics Institute, University of Minnesota, 1500 Gortner Avenue, St. Paul, MN 55108, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Glazebrook","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Cell Biology, The University of Chicago, 1103 East 57th Street EBC410, Chicago, IL 60637, USA."},{"name":"Oak Ridge National Laboratory, Environmental Sciences Division, Oak Ridge, TN 37831\u20136341, USA."},{"name":"Department of Plant Biology, Microbial and Plant Genomics Institute, University of Minnesota, 1500 Gortner Avenue, St. Paul, MN 55108, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean T.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Cell Biology, The University of Chicago, 1103 East 57th Street EBC410, Chicago, IL 60637, USA."},{"name":"Oak Ridge National Laboratory, Environmental Sciences Division, Oak Ridge, TN 37831\u20136341, USA."},{"name":"Department of Plant Biology, Microbial and Plant Genomics Institute, University of Minnesota, 1500 Gortner Avenue, St. Paul, MN 55108, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2307\/3870231"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00962"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1365-313X.2007.03400.x","volume":"54","year":"2008","unstructured":"R. Chaturvediet al., Plant J.54, 106 (2008).","journal-title":"Plant J."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1094\/Phyto-76-966"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605423104"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.10.9.1571"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.016907"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.250.4983.1002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1147113"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2008.03618.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/pmpp.1999.0214"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2006.02972.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2006.03017.x"},{"key":"e_1_3_2_15_2","unstructured":"This work was funded by NSF grants to J.T.G. (IOB-0450207) and J.G. (IOB-0419648) and by a fellowship from Korea Research Foundation to H.W.J. and T.J.T. was supported by the Office of Biological and Environmental Research of the U.S. Department of Energy. Oak Ridge National Laboratory is managed by UT-Battelle for the U.S. Department of Energy under contract DE-AC05-00OR22725. We thank J. Bergelson and L. Mets for the use of their high-performance liquid chromatographys F. Katagiri and J. Malamy for useful discussions R. Cameron for sharing her detailed exudate collection protocol and N. Engle for analysis of exudates. A patent application related to this work has been filed by the University of Chicago and UT-Battelle on behalf of inventors J.T.G. H.W.J. and T.J.T. on the use of azelaic acid to confer protection in crop plants against infection."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1170025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:37:39Z","timestamp":1704861459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1170025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,3]]},"references-count":14,"journal-issue":{"issue":"5923","published-print":{"date-parts":[[2009,4,3]]}},"alternative-id":["10.1126\/science.1170025"],"URL":"https:\/\/doi.org\/10.1126\/science.1170025","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1159027.619309","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,3]]}}}