{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:19:24Z","timestamp":1791980364616,"version":"4.4.0"},"reference-count":25,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5923","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,4,3]]},"abstract":"<jats:p>Mitochondria continuously undergo two opposing processes, fission and fusion. The disruption of this dynamic equilibrium may herald cell injury or death and may contribute to developmental and neurodegenerative disorders. Nitric oxide functions as a signaling molecule, but in excess it mediates neuronal injury, in part via mitochondrial fission or fragmentation. However, the underlying mechanism for nitric oxide\u2013induced pathological fission remains unclear. We found that nitric oxide produced in response to \u03b2-amyloid protein, thought to be a key mediator of Alzheimer's disease, triggered mitochondrial fission, synaptic loss, and neuronal damage, in part via S-nitrosylation of dynamin-related protein 1 (forming SNO-Drp1). Preventing nitrosylation of Drp1 by cysteine mutation abrogated these neurotoxic events. SNO-Drp1 is increased in brains of human Alzheimer's disease patients and may thus contribute to the pathogenesis of neurodegeneration.<\/jats:p>","DOI":"10.1126\/science.1171091","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T17:36:39Z","timestamp":1238693799000},"page":"102-105","source":"Crossref","is-referenced-by-count":1011,"title":["S-Nitrosylation of Drp1 Mediates \u03b2-Amyloid-Related Mitochondrial Fission and Neuronal Injury"],"prefix":"10.1126","volume":"324","author":[{"given":"Dong-Hyung","family":"Cho","sequence":"first","affiliation":[{"name":"Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."},{"name":"Bioinformatics and Systems Biology Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."},{"name":"Bioinformatics and Systems Biology Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Fang","sequence":"additional","affiliation":[{"name":"Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."},{"name":"Bioinformatics and Systems Biology Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Cieplak","sequence":"additional","affiliation":[{"name":"Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."},{"name":"Bioinformatics and Systems Biology Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Godzik","sequence":"additional","affiliation":[{"name":"Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."},{"name":"Bioinformatics and Systems Biology Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezong","family":"Gu","sequence":"additional","affiliation":[{"name":"Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."},{"name":"Bioinformatics and Systems Biology Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA."},{"name":"Bioinformatics and Systems Biology Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, 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thank T. Newmeyer J. Zaremba J. Russo E. Masliah H. Xu and Y. Zhang for help or reagents. Supported by the Japan Society for the Promotion of Science (T.N.) and NIH grants P01 HD29587 R01 EY05477 P01 ES016738 and P30 NS057096 (S.A.L.)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1171091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:37:04Z","timestamp":1704861424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1171091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,3]]},"references-count":25,"journal-issue":{"issue":"5923","published-print":{"date-parts":[[2009,4,3]]}},"alternative-id":["10.1126\/science.1171091"],"URL":"https:\/\/doi.org\/10.1126\/science.1171091","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1159697.623055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1159697.621098","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,3]]}}}