{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:44:07Z","timestamp":1792737847947,"version":"4.5.0"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5938","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,7,17]]},"abstract":"<jats:title>Plethora of Secretory Amyloids<\/jats:title>\n                  <jats:p>\n                    Protein aggregation and the formation of amyloids are associated with several dozen pathological conditions in humans, including Alzheimer's disease, Parkinson's disease, and type II diabetes. In addition, a few functional amyloid systems are known: the prions of fungi, the bacterial protein curli, the protein of chorion of the eggshell of silkworm, and the amyloid protein Pmel-17 involved in mammalian skin pigmentation. Now\n                    <jats:bold>\n                      Maji\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"328\" related-article-type=\"in-this-issue\" vol=\"325\" xlink:href=\"10.1126\/science.1173155\">328<\/jats:related-article>\n                    , published online 18 June) propose that endocrine hormone peptides and proteins are stored in an amyloid-like state in secretory granules. Thus, the amyloid fold may represent a fundamental, ancient, and evolutionarily conserved protein structural motif that is capable of performing a wide variety of functions contributing to normal cell and tissue physiology.\n                  <\/jats:p>","DOI":"10.1126\/science.1173155","type":"journal-article","created":{"date-parts":[[2009,6,18]],"date-time":"2009-06-18T21:44:12Z","timestamp":1245361452000},"page":"328-332","source":"Crossref","is-referenced-by-count":1006,"title":["Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules"],"prefix":"10.1126","volume":"325","author":[{"given":"Samir K.","family":"Maji","sequence":"first","affiliation":[{"name":"Laboratory of Physical Chemistry, Eidgen\u00f6ssische Technische Hochschule (ETH) Z\u00fcrich, Wolfgang-Paulistrasse 10, CH-8093 Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn H.","family":"Perrin","sequence":"additional","affiliation":[{"name":"Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Sawaya","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Box 951570, University of California, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Jessberger","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Vadodaria","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Rissman","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praful S.","family":"Singru","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA 02111, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Peter R.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, IFM, Link\u00f6ping University, SE-581 83 Link\u00f6ping, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozalyn","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Chemistry, IFM, Link\u00f6ping University, SE-581 83 Link\u00f6ping, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schubert","sequence":"additional","affiliation":[{"name":"Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Box 951570, University of California, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Rivier","sequence":"additional","affiliation":[{"name":"Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Sawchenko","sequence":"additional","affiliation":[{"name":"Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wylie","family":"Vale","sequence":"additional","affiliation":[{"name":"Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Riek","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Chemistry, Eidgen\u00f6ssische Technische Hochschule (ETH) Z\u00fcrich, Wolfgang-Paulistrasse 10, CH-8093 Z\u00fcrich, Switzerland."},{"name":"Structural Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2994224"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/326014a0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3320593"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(01)00437-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00344-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(98)00059-7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.31.2.349"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:22:1-2:43"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2007.03.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.60.080805.142106"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01888-3"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.072199199"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040006"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20031230"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.77.2.288"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.86.1.260"},{"key":"e_1_3_2_18_2","first-page":"94","volume":"31","author":"Rosa P.","year":"1983","unstructured":"Rosa P., Zanini A., Eur. 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