{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:35:45Z","timestamp":1791333345089,"version":"4.3.1"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5944","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,8,28]]},"abstract":"<jats:title>Beat It<\/jats:title>\n                  <jats:p>\n                    Primary cilia are specialized organelles that serve important sensory functions in many different tissues and cells, and defects in their structure and function underlie a variety of genetic diseases. In contrast to primary cilia, motile cilia serve a mechanical function. For example, the cilia on airway epithelia remove inhaled material from the lung.\n                    <jats:bold>\n                      Shah\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1131\" related-article-type=\"in-this-issue\" vol=\"325\" xlink:href=\"10.1126\/science.1173869\">1131<\/jats:related-article>\n                    , published online 23 July; see the cover; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"5944\" page=\"1081\" related-article-type=\"in-this-issue\" vol=\"325\" xlink:href=\"10.1126\/science.1179180\">Kinnamon and Reynolds<\/jats:related-article>\n                    <\/jats:bold>\n                    ) now show that these classic motile cilia are also chemosensory. The motile cilia on airway epithelia contain bitter-taste receptors and their associated signaling machinery. Moreover, application of bitter substances triggers an elevation of intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    levels and increases cilia beat frequency. Thus, in airway epithelia, bitter-taste receptors may be able to detect noxious substances entering the airways and initiate an autonomous defensive mechanism designed to accelerate elimination of the offending compound.\n                  <\/jats:p>","DOI":"10.1126\/science.1173869","type":"journal-article","created":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T22:06:22Z","timestamp":1248386782000},"page":"1131-1134","source":"Crossref","is-referenced-by-count":685,"title":["Motile Cilia of Human Airway Epithelia Are Chemosensory"],"prefix":"10.1126","volume":"325","author":[{"given":"Alok S.","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Ben-Shahar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Howard Hughes Medical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas O.","family":"Moninger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel N.","family":"Kline","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Welsh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Howard Hughes Medical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124534"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.07.012"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2278"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.03.002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00511-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00118.2005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(08)00803-X"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712327105"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708571104"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.053"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.20273"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1652"},{"key":"e_1_3_2_14_2","unstructured":"P. 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