{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:14:11Z","timestamp":1792037651751,"version":"4.4.0"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5939","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,7,24]]},"abstract":"<jats:title>Keeping Calm<\/jats:title>\n                  <jats:p>\n                    Benzodiazepines are the most prescribed anxiolytics and are used by a broad population. However, benzodiazepines can cause unwanted side effects, including sedation, development of tolerance, and withdrawal symptoms after long-term administration.\n                    <jats:bold>\n                      Rupprecht\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"490\" related-article-type=\"in-this-issue\" vol=\"325\" xlink:href=\"10.1126\/science.1175055\">490<\/jats:related-article>\n                    ; published online 18 June) now find that a translocator protein (18-kD) ligand, XBD173, is a fast-acting anxiolytic agent, both in animals and humans, which lacks the unwanted side effects of benzodiazepines and provides a promising target for novel clinically effective anxiolytic drugs.\n                  <\/jats:p>","DOI":"10.1126\/science.1175055","type":"journal-article","created":{"date-parts":[[2009,6,18]],"date-time":"2009-06-18T21:44:12Z","timestamp":1245361452000},"page":"490-493","source":"Crossref","is-referenced-by-count":296,"title":["Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects"],"prefix":"10.1126","volume":"325","author":[{"given":"Rainer","family":"Rupprecht","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, Munich 80336, Germany."},{"name":"Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2, Munich 80804, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Rammes","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2, Munich 80804, Germany."},{"name":"Department of Anaesthesiology, Technische Universit\u00e4t, Munich 81675, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Eser","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, Munich 80336, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Baghai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, Munich 80336, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius","family":"Sch\u00fcle","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, Munich 80336, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Nothdurfter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, Munich 80336, Germany."},{"name":"Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2, Munich 80804, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Troxler","sequence":"additional","affiliation":[{"name":"Novartis Institute for Biomedical Research (NIBR), Neuroscience, 4056 Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad","family":"Gentsch","sequence":"additional","affiliation":[{"name":"Novartis Institute for Biomedical Research (NIBR), Neuroscience, 4056 Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans O.","family":"Kalkman","sequence":"additional","affiliation":[{"name":"Novartis Institute for Biomedical Research (NIBR), Neuroscience, 4056 Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederique","family":"Chaperon","sequence":"additional","affiliation":[{"name":"Novartis Institute for Biomedical Research (NIBR), Neuroscience, 4056 Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veska","family":"Uzunov","sequence":"additional","affiliation":[{"name":"Novartis Institute for Biomedical Research (NIBR), Neuroscience, 4056 Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin H.","family":"McAllister","sequence":"additional","affiliation":[{"name":"Novartis Institute for Biomedical Research (NIBR), Neuroscience, 4056 Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Bertaina-Anglade","sequence":"additional","affiliation":[{"name":"Biotrial, 3500 Rennes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe Drieu","family":"La Rochelle","sequence":"additional","affiliation":[{"name":"Biotrial, 3500 Rennes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"Tuerck","sequence":"additional","affiliation":[{"name":"Drug Metabolism and Pharmacokinetics, F. 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