{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:10:38Z","timestamp":1791443438929,"version":"4.3.3"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5950","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,10,9]]},"abstract":"<jats:title>Containing Neuronal Exuberance<\/jats:title>\n                  <jats:p>\n                    In rats and mice, around the time of birth, neurons of the central nervous system switch from a growth mode and lose their ability to regenerate. Studying retinal ganglion cells of the rat,\n                    <jats:bold>\n                      Moore\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"298\" related-article-type=\"in-this-issue\" vol=\"326\" xlink:href=\"10.1126\/science.1175737\">298<\/jats:related-article>\n                    ; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"5950\" page=\"238\" related-article-type=\"in-this-issue\" vol=\"326\" xlink:href=\"10.1126\/science.1181038\">Subang and Richardson<\/jats:related-article>\n                    <\/jats:bold>\n                    ) identified a gene,\n                    <jats:italic>Kr\u00fcppel-like factor-4<\/jats:italic>\n                    (\n                    <jats:italic>KLF4<\/jats:italic>\n                    ), that seems to contribute to the switch. The\n                    <jats:italic>KLF4<\/jats:italic>\n                    gene belongs to a family of related transcription factors that possess repressive or enhancing effects on axon growth. The combinatorial effect of this family of transcription factors before and after birth may fine-tune the ability of the neurons to extend axons.\n                  <\/jats:p>","DOI":"10.1126\/science.1175737","type":"journal-article","created":{"date-parts":[[2009,10,8]],"date-time":"2009-10-08T17:50:01Z","timestamp":1255024201000},"page":"298-301","source":"Crossref","is-referenced-by-count":690,"title":["KLF Family Members Regulate Intrinsic Axon Regeneration Ability"],"prefix":"10.1126","volume":"326","author":[{"given":"Darcie L.","family":"Moore","sequence":"first","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA."},{"name":"Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray G.","family":"Blackmore","sequence":"additional","affiliation":[{"name":"Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hu","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus H.","family":"Kaestner","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Bixby","sequence":"additional","affiliation":[{"name":"Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA."},{"name":"Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vance P.","family":"Lemmon","sequence":"additional","affiliation":[{"name":"Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA."},{"name":"Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA."},{"name":"Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(96)10021-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.16.7287"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902820304"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1956"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.09.008"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068428"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20224"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-10-03710.1997"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-23-08318.2003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb01106.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04731.2001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.10.030"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/385434a0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01658"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-17-07537.1999"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093712"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04895"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161566"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4488-06.2007"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.2144\/000112279"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.11.013"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210022"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.465"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.6.2055-2064.2006"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/11926"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.11.2619"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-2-206"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1698"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804831200"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf400"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.143.6.2242"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.09.019"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290271"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2004.07.002"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1780"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.08.006"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1111"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21871"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.036"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1175737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T03:22:10Z","timestamp":1704856930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1175737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,9]]},"references-count":39,"journal-issue":{"issue":"5950","published-print":{"date-parts":[[2009,10,9]]}},"alternative-id":["10.1126\/science.1175737"],"URL":"https:\/\/doi.org\/10.1126\/science.1175737","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1167957.630055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1167957.6558054","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,9]]}}}