{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:56:07Z","timestamp":1793307367525,"version":"4.5.0"},"reference-count":51,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5958","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,12,4]]},"abstract":"<jats:title>Zeroing in on Zoonoses<\/jats:title>\n          <jats:p>\n            Influenza, plague, and Lyme disease are classic examples of zoonoses\u2014diseases that circulate in livestock and wildlife, as well as in humans. When a pathogen transfers among multiple hosts, the dynamics of circulation, transmission, and outbreak are complex.\n            <jats:bold>\n              Lloyd-Smith\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1362\" related-article-type=\"in-this-issue\" vol=\"326\" xlink:href=\"10.1126\/science.1177345\">1362<\/jats:related-article>\n            ) review the use of analytical mathematical tools, particularly modeling, in the development of control policies and research agendas. Significant gaps are highlighted in analytical efforts during spillover transmission from animals into humans. Moreover, the tendency has been to focus on pathogens with simpler life cycles and of immediate global urgency, such as influenza, whereas insect-transmitted pathogens with complex, multihost life cycles are less well understood.\n          <\/jats:p>","DOI":"10.1126\/science.1177345","type":"journal-article","created":{"date-parts":[[2009,12,4]],"date-time":"2009-12-04T00:15:50Z","timestamp":1259885750000},"page":"1362-1367","source":"Crossref","is-referenced-by-count":624,"title":["Epidemic Dynamics at the Human-Animal Interface"],"prefix":"10.1126","volume":"326","author":[{"given":"James O.","family":"Lloyd-Smith","sequence":"first","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, University of California at Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"George","sequence":"additional","affiliation":[{"name":"Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA."},{"name":"Department of Biology, Colorado State University, Fort Collins, CO 80523, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim M.","family":"Pepin","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia E.","family":"Pitzer","sequence":"additional","affiliation":[{"name":"Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA."},{"name":"Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet R. C.","family":"Pulliam","sequence":"additional","affiliation":[{"name":"Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Dobson","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, and Woodrow Wilson School, Princeton University, Princeton, NJ 08544, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA."},{"name":"Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan T.","family":"Grenfell","sequence":"additional","affiliation":[{"name":"Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA."},{"name":"Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA."},{"name":"Department of Ecology and Evolutionary Biology, and Woodrow Wilson School, Princeton University, Princeton, NJ 08544, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.3201\/eid1112.050997","volume":"11","author":"Woolhouse M. 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