{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:44:55Z","timestamp":1791398695227,"version":"4.3.3"},"reference-count":26,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5949","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,10,2]]},"abstract":"<jats:title>Dog Coats Shed Genetic Secrets<\/jats:title>\n                  <jats:p>\n                    The coats of domestic dogs show great variation\u2014long, short, straight, wavy, curly, wiry, or smooth. To investigate how this variation arises,\n                    <jats:bold>\n                      Cadieu\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"150\" related-article-type=\"in-this-issue\" vol=\"326\" xlink:href=\"10.1126\/science.1177808\">150<\/jats:related-article>\n                    , published online 27 August) performed genome-wide association studies on 80 different dog breeds. The coat phenotype could be dissected into three simple traits of length, curl, and growth pattern or texture with each trait controlled by one major gene,\n                    <jats:italic>FGF5<\/jats:italic>\n                    (fibroblast growth factor-5),\n                    <jats:italic>KRT71<\/jats:italic>\n                    (keratin-71), and\n                    <jats:italic>RSPO2<\/jats:italic>\n                    (R-spondin-2), respectively. In combination, variants in these three genes alone account for the vast majority of the coat phenotypes in purebred dogs in the United States. Thus, a small number of simply inherited traits can be remixed to create extraordinary phenotypic variation.\n                  <\/jats:p>","DOI":"10.1126\/science.1177808","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T22:00:33Z","timestamp":1251410433000},"page":"150-153","source":"Crossref","is-referenced-by-count":307,"title":["Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes"],"prefix":"10.1126","volume":"326","author":[{"given":"Edouard","family":"Cadieu","sequence":"first","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Neff","sequence":"additional","affiliation":[{"name":"Veterinary Genetics Laboratory, University of California, Davis, CA, 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Quignon","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Walsh","sequence":"additional","affiliation":[{"name":"Veterinary Genetics Laboratory, University of California, Davis, CA, 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Chase","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Utah, Salt Lake City, UT 84112, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi G.","family":"Parker","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridgett M.","family":"VonHoldt","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Rhue","sequence":"additional","affiliation":[{"name":"Veterinary Genetics Laboratory, University of California, Davis, CA, 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Boyko","sequence":"additional","affiliation":[{"name":"Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Byers","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Wong","sequence":"additional","affiliation":[{"name":"Veterinary Genetics Laboratory, University of California, Davis, CA, 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana S.","family":"Mosher","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel G.","family":"Elkahloun","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyrone C.","family":"Spady","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"UMR 6061, CNRS, Universit\u00e9 de Rennes 1, Facult\u00e9 de M\u00e9decine, CS 34317, Rennes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Gordon","family":"Lark","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Utah, Salt Lake City, UT 84112, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Cargill","sequence":"additional","affiliation":[{"name":"Affymetrix Corporation, Santa Clara, CA 95051, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos D.","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Wayne","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine A.","family":"Ostrander","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5319.1687"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073906"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137045"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.10"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04338"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2007.08.013"},{"key":"e_1_3_2_8_2","unstructured":"American Kennel Club The Complete Dog Book . 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