{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:53:10Z","timestamp":1794491590258,"version":"4.9.1"},"reference-count":32,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5959","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,12,11]]},"abstract":"<jats:title>Ghosts of Selection<\/jats:title>\n          <jats:p>\n            Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency of humans, and it has been long suspected to exert an effect on\n            <jats:italic>Plasmodium falciparum<\/jats:italic>\n            malaria in Africa. Likewise, the increase in prevalence of the G6PD-Mahidol 487\n            <jats:sup>A<\/jats:sup>\n            allele among Karen people in Thailand, who only in the past few thousand years have migrated into malarious zones, may be the result of selection by\n            <jats:italic>Plasmodium vivax<\/jats:italic>\n            malaria.\n            <jats:italic>P. vivax<\/jats:italic>\n            has recently been implicated in more severe disease than previously suspected, providing both a direct selective effect through mortality and an indirect selective effect through morbidity and reproductive failure.\n            <jats:bold>\n              Louicharoen\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1546\" related-article-type=\"in-this-issue\" vol=\"326\" xlink:href=\"10.1126\/science.1178849\">1546<\/jats:related-article>\n            ) link population-genetic evidence for positive selection in an 8-year family-based study of 3000 Karen individuals and reveal that there is an association between the presence of the G6PD-Mahidol 487\n            <jats:sup>A<\/jats:sup>\n            allele and a reduction in the density of\n            <jats:italic>P. vivax<\/jats:italic>\n            parasites circulating in the bloodstreams of infected individuals. The mutation appears to exert its effect on the physiology of immature red blood cells, which are the preferred niche for\n            <jats:italic>P. vivax<\/jats:italic>\n            but not of\n            <jats:italic>P. falciparum<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1126\/science.1178849","type":"journal-article","created":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T22:53:04Z","timestamp":1260485584000},"page":"1546-1549","source":"Crossref","is-referenced-by-count":160,"title":["Positively Selected\n            <i>G6PD<\/i>\n            -Mahidol Mutation Reduces\n            <i>Plasmodium<\/i>\n            <i>vivax<\/i>\n            Density in Southeast Asians"],"prefix":"10.1126","volume":"326","author":[{"given":"Chalisa","family":"Louicharoen","sequence":"first","affiliation":[{"name":"Institut Pasteur, Laboratoire de la G\u00e9n\u00e9tique de la r\u00e9ponse aux infections chez l'homme, 75724 Paris, France."},{"name":"Interdepartmental Program of Biomedical Science, Faculty of the Graduate School, Chulalongkorn University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Patin","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Human Evolutionary Genetics Unit, CNRS, URA3012, 75015 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Paul","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Laboratoire de la G\u00e9n\u00e9tique de la r\u00e9ponse aux infections chez l'homme, 75724 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issarang","family":"Nuchprayoon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhee","family":"Witoonpanich","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Laboratoire de la G\u00e9n\u00e9tique de la r\u00e9ponse aux infections chez l'homme, 75724 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chayanon","family":"Peerapittayamongkol","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Laboratoire de la G\u00e9n\u00e9tique de la r\u00e9ponse aux infections chez l'homme, 75724 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Casademont","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Laboratoire de la G\u00e9n\u00e9tique de la r\u00e9ponse aux infections chez l'homme, 75724 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanyachai","family":"Sura","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan M.","family":"Laird","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratap","family":"Singhasivanon","sequence":"additional","affiliation":[{"name":"Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluis","family":"Quintana-Murci","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Human Evolutionary Genetics Unit, CNRS, URA3012, 75015 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anavaj","family":"Sakuntabhai","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Laboratoire de la G\u00e9n\u00e9tique de la r\u00e9ponse aux infections chez l'homme, 75724 Paris, France."},{"name":"Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/432519"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1182\/blood.V84.11.3613.bloodjournal84113613","volume":"84","author":"Beutler E.","year":"1994","unstructured":"Beutler E., Blood 84, 3613 (1994).7949118","journal-title":"Blood"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01140"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061573"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1093\/genetics\/162.4.1849","volume":"162","author":"Saunders M. 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