{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:08:12Z","timestamp":1792670892916,"version":"4.5.0"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5963","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,1,15]]},"abstract":"<jats:title>Targeting Copper Clusters<\/jats:title>\n                  <jats:p>\n                    Tetrathiomolybdate (TM) is a copper-depleting agent that has potential in treating copper-dependent diseases.\n                    <jats:bold>\n                      Alvarez\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"331\" related-article-type=\"in-this-issue\" vol=\"327\" xlink:href=\"10.1126\/science.1179907\">331<\/jats:related-article>\n                    , published online 26 November) used spectroscopic and structural studies to show that TM inhibits the yeast copper chaperone Atx1 by forming a TM-Cu-ATx1 complex that is stabilized by a sulfur-bridged copper-molybdenum cluster. Cluster formation prevents transfer of copper from the chaperone to target enzymes. The results provide a basis for developing drugs that target metallation pathways.\n                  <\/jats:p>","DOI":"10.1126\/science.1179907","type":"journal-article","created":{"date-parts":[[2009,11,27]],"date-time":"2009-11-27T18:42:01Z","timestamp":1259347321000},"page":"331-334","source":"Crossref","is-referenced-by-count":194,"title":["Tetrathiomolybdate Inhibits Copper Trafficking Proteins Through Metal Cluster Formation"],"prefix":"10.1126","volume":"327","author":[{"given":"Hamsell M.","family":"Alvarez","sequence":"first","affiliation":[{"name":"The Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xue","sequence":"additional","affiliation":[{"name":"The Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandler D.","family":"Robinson","sequence":"additional","affiliation":[{"name":"The Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica A.","family":"Canalizo-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"The Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca G.","family":"Marvin","sequence":"additional","affiliation":[{"name":"The Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah A.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Mondrag\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Penner-Hahn","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas V.","family":"O\u2019Halloran","sequence":"additional","affiliation":[{"name":"The Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA."},{"name":"Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/141553a0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/185020a0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020222600712"},{"key":"e_1_3_2_5_2","unstructured":"J. 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