{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:41:08Z","timestamp":1793194868342,"version":"4.5.0"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5965","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,1,29]]},"abstract":"<jats:title>Platelet Microparticles Drive Inflammatory Arthritis<\/jats:title>\n                  <jats:p>\n                    Platelets are best known for their critical role in blood clot formation during wound repair, but an appreciation for their role in inflammatory processes is growing. Platelet-derived cellular microparticles (MPs) are small membrane vesicles released from platelets in response to cell activation that can transport biomolecules throughout the body that have also been implicated in inflammatory processes.\n                    <jats:bold>\n                      Boilard\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"580\" related-article-type=\"in-this-issue\" vol=\"327\" xlink:href=\"10.1126\/science.1181928\">580<\/jats:related-article>\n                    ; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"5965\" page=\"528\" related-article-type=\"in-this-issue\" vol=\"327\" xlink:href=\"10.1126\/science.1185869\">Zimmerman and Weyrich<\/jats:related-article>\n                    <\/jats:bold>\n                    ) have now found that platelet-derived MPs probably contribute to the inflammatory processes underlying rheumatoid arthritis, an autoimmune disease. The majority of MPs in synovial fluid from patients with various types of inflammatory arthritis were platelet-derived and, importantly, platelet-derived MPs were lacking in synovial fluid from osteoarthritis patients. Furthermore, platelet depletion abrogated disease development in a mouse model of inflammatory arthritis.\n                  <\/jats:p>","DOI":"10.1126\/science.1181928","type":"journal-article","created":{"date-parts":[[2010,1,28]],"date-time":"2010-01-28T14:25:29Z","timestamp":1264688729000},"page":"580-583","source":"Crossref","is-referenced-by-count":987,"title":["Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production"],"prefix":"10.1126","volume":"327","author":[{"given":"Eric","family":"Boilard","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Nigrovic","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Division of Immunology, Children\u2019s Hospital Boston, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Larabee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald F. M.","family":"Watts","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Coblyn","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Weinblatt","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena M.","family":"Massarotti","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Remold-O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Immune Disease Institute, Harvard Medical School, Boston MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Farndale","sequence":"additional","affiliation":[{"name":"University of Cambridge, Department of Biochemistry, Downing Site, Cambridge CB2 1QW, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Ware","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Little Rock, AR 72205\u20137199, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"L. 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