{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:19:39Z","timestamp":1792196379856,"version":"4.4.0"},"reference-count":53,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5963","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,1,15]]},"abstract":"<jats:p>Interleukin-1\u03b2 (IL-1\u03b2), reactive oxygen species (ROS), and thioredoxin-interacting protein (TXNIP) are all implicated in the pathogenesis of type 2 diabetes mellitus (T2DM). Here we review mechanisms directing IL-1\u03b2 production and its pathogenic role in islet dysfunction during chronic hyperglycemia. In doing so, we integrate previously disparate disease-driving mechanisms for IL-1\u03b2, ROS, and TXNIP in T2DM into one unifying model in which the NLRP3 inflammasome plays a central role. The NLRP3 inflammasome also drives IL-1\u03b2 maturation and secretion in another disease of metabolic dysregulation, gout. Thus, we propose that the NLRP3 inflammasome contributes to the pathogenesis of T2DM and gout by functioning as a sensor for metabolic stress.<\/jats:p>","DOI":"10.1126\/science.1184003","type":"journal-article","created":{"date-parts":[[2010,1,14]],"date-time":"2010-01-14T19:38:48Z","timestamp":1263497928000},"page":"296-300","source":"Crossref","is-referenced-by-count":1022,"title":["The NLRP3 Inflammasome: A Sensor for Metabolic Danger?"],"prefix":"10.1126","volume":"327","author":[{"given":"Kate","family":"Schroder","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland."},{"name":"Monash Institute of Medical Research, Monash University, Melbourne, Victoria 3800, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongbin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurg","family":"Tschopp","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.3.812"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712590903136688"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1650"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.4.738"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.1.102"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s125-002-8248-z"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-003-0450-y"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200215318"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1683"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132715"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.05.074"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0396"},{"key":"e_1_3_1_14_2","author":"Zhou R.","unstructured":"Zhou R., Tardivel A., Thorens B., Choi I., Tschopp J., Nat. Immunol., published online 20 December 2009 (10.1038\/ni.1831).","journal-title":"Nat. Immunol."},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1430"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1059"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0543"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02427283"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00403185"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1130551"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302351"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.07.004"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0533"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065213"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.01.006"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2009.06.002"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.02.011"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00494.2003"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.03.008"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1631"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00730-09"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156995"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803933105"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608083200"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1633"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800293105"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0646"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1378"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040158"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0715"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2143"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108936"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920209787847023"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0462-6"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.1458"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28898"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0543"},{"key":"e_1_3_1_49_2","first-page":"6231","article-title":"Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: Evidence for a positive autoregulatory loop.","volume":"13","author":"Hiscott J.","year":"1993","unstructured":"Hiscott J., et al.., Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: Evidence for a positive autoregulatory loop. Mol. Cell. Biol. 13, 6231 (1993).8413223","journal-title":"Mol. Cell. Biol."},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(92)90321-R"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06664"},{"key":"e_1_3_1_52_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200903124"},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07965"},{"key":"e_1_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.023689"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1184003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T09:10:10Z","timestamp":1704877810000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1184003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,15]]},"references-count":53,"journal-issue":{"issue":"5963","published-print":{"date-parts":[[2010,1,15]]}},"alternative-id":["10.1126\/science.1184003"],"URL":"https:\/\/doi.org\/10.1126\/science.1184003","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,15]]}}}