{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:37:14Z","timestamp":1791333434168,"version":"4.3.1"},"reference-count":61,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5980","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,5,14]]},"abstract":"<jats:p>\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            has a penetrance of its host population that would be the envy of most human pathogens. About one-third of the human population would have a positive skin test for the infection and is thus thought to harbor the bacterium. Globally, 22 \u201chigh-burden\u201d countries account for more than 80% of the active tuberculosis cases in the world, which shows the inequitable distribution of the disease. There is no effective vaccine against infection, and current drug therapies are fraught with problems, predominantly because of the protracted nature of the treatment and the increasing occurrence of drug resistance. Here we focus on the biology of the host-pathogen interaction and discuss new and evolving strategies for intervention.\n          <\/jats:p>","DOI":"10.1126\/science.1184784","type":"journal-article","created":{"date-parts":[[2010,5,13]],"date-time":"2010-05-13T22:41:57Z","timestamp":1273790517000},"page":"852-856","source":"Crossref","is-referenced-by-count":422,"title":["Tuberculosis: What We Don\u2019t Know Can, and Does, Hurt Us"],"prefix":"10.1126","volume":"328","author":[{"given":"David G.","family":"Russell","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"3rd","given":"Clifton E.","family":"Barry","sequence":"additional","affiliation":[{"name":"Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, Building 33, Room 2W20D, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnne L.","family":"Flynn","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, W1144 Biomedical Science Tower, Pittsburgh, PA 15261, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2005.01.005"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1538"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1781"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01515-07"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.12.7099-7108.2003"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0903"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2236"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2009.02458.x"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90085-3"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.312.5782.1874b"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.6954-6961.2000"},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/art.27271","article-title":"Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model","volume":"62","author":"Lin P. 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