{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:12:09Z","timestamp":1791547929339,"version":"4.3.4"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5989","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,7,16]]},"abstract":"Golden Regulator<\/jats:title>\n \n Staphylococcus aureus<\/jats:italic>\n is a common cause of intractable infections that are exacerbated by an array of toxins and virulence factors. The\n agr<\/jats:italic>\n pheromone has been thought to represent the master regulator of virulence in this pathogen, but it is not always expressed and is also found in many nonpathogenic cocci. A strictly conserved, nonribosomal peptide synthetase has now been found by\n \n Wyatt\n et al.<\/jats:italic>\n <\/jats:bold>\n (p.\n 294<\/jats:related-article>\n , published online 3 June) by genome mining. The enzyme assembles valine and tyrosine into cyclic dipeptides called aureusimines that are expressed by all sequenced strains of\n S. aureus<\/jats:italic>\n , including the \u201csuperbug\u201d MRSA (Methicillin-resistant\n Staphylococcus aureus<\/jats:italic>\n ). Microarray analysis showed a striking effect of mutation in the synthetase locus on the production of immunomodulators, hemolysins, and other exotoxins by the pathogen. Indeed, mice infected systemically with the mutant strain showed a restricted spread of infection compared with the wild type.\n <\/jats:p>","DOI":"10.1126\/science.1188888","type":"journal-article","created":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T22:47:00Z","timestamp":1275605220000},"page":"294-296","source":"Crossref","is-referenced-by-count":121,"title":["Staphylococcus aureus<\/i>\n Nonribosomal Peptide Secondary Metabolites Regulate Virulence"],"prefix":"10.1126","volume":"329","author":[{"given":"Morgan A.","family":"Wyatt","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences, Department of Chemistry and Chemical Biology, M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8N 3Z5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences, Department of Chemistry and Chemical Biology, M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8N 3Z5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle M.","family":"Roux","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico C.","family":"Beasley","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, and Centre for Human Immunology, University of Western Ontario, London, Ontario N6A 5C1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Heinrichs","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, and Centre for Human Immunology, University of Western Ontario, London, Ontario N6A 5C1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Dunman","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A.","family":"Magarvey","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences, Department of Chemistry and Chemical Biology, M. 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