{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:20:04Z","timestamp":1789611604147,"version":"build-2803163510"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5996","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,9,3]]},"abstract":"<jats:title>Here to Stay<\/jats:title>\n          <jats:p>\n            For systemic infection, bacterial pathogens must breach the mucosal epithelial barrier. Our bodies have developed a variety of strategies to protect the mucosa, including rapid turnover of epithelial cells.\n            <jats:bold>\n              Muenzner\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1197\" related-article-type=\"in-this-issue\" vol=\"329\" xlink:href=\"10.1126\/science.1190892\">1197<\/jats:related-article>\n            ; see the cover) show how invasive bacteria overcome this host defense in a humanized mouse model susceptible to\n            <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n            urogenital infection. The bacteria bind to a host-cell surface protein called carcinoembryonic antigen (CEA), which triggers a cascade of changes modulating the cell adhesion properties of the targeted epithelium to prevent the cells from being shed.\n          <\/jats:p>","DOI":"10.1126\/science.1190892","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T19:25:55Z","timestamp":1283455555000},"page":"1197-1201","source":"Crossref","is-referenced-by-count":85,"title":["Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation"],"prefix":"10.1126","volume":"329","author":[{"given":"Petra","family":"Muenzner","sequence":"first","affiliation":[{"name":"Lehrstuhl Zellbiologie, Fachbereich Biologie, Universit\u00e4t Konstanz, 78457 Konstanz, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Lehrstuhl Zellbiologie, Fachbereich Biologie, Universit\u00e4t Konstanz, 78457 Konstanz, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Tumor Immunology Laboratory, LIFE Center, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 81377 M\u00fcnchen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Hentschel","sequence":"additional","affiliation":[{"name":"Lehrstuhl Zellbiologie, Fachbereich Biologie, Universit\u00e4t Konstanz, 78457 Konstanz, Germany."},{"name":"EM Service, Fachbereich Biologie, Universit\u00e4t Konstanz, 78457 Konstanz, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof R.","family":"Hauck","sequence":"additional","affiliation":[{"name":"Lehrstuhl Zellbiologie, Fachbereich Biologie, Universit\u00e4t Konstanz, 78457 Konstanz, Germany."},{"name":"Konstanz Research School Chemical Biology, Universit\u00e4t Konstanz, 78457 Konstanz, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"J. 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