{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:28:20Z","timestamp":1792099700290,"version":"4.4.0"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6009","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,12,3]]},"abstract":"<jats:title>Pain in the Brain<\/jats:title>\n                  <jats:p>\n                    One of the major challenges in pain research is finding ways to reverse chronic pain. Synaptic long-term potentiation (LTP) at spinal or cortical levels is a cellular model of chronic pain.\n                    <jats:bold>\n                      X.-Y. Li.\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1400\" related-article-type=\"in-this-issue\" vol=\"330\" xlink:href=\"10.1126\/science.1191792\">1400<\/jats:related-article>\n                    ) studied the role of the enzyme protein kinase M zeta (PKM\u03b6) in neurons of the anterior cingulate cortex (ACC) in the maintenance of LTP and for enhanced pain sensitivity after peripheral nerve injury in mice. Nerve injury appeared to lead to the up-regulation and phosphorylation of PKM\u03b6. This triggered LTP at some synapses in the ACC by increasing the number of AMPA receptors. LTP was restricted to ACC neurons that were activated by nerve injury. Blocking PKM\u03b6 in the ACC days after nerve injury normalized pain behavior. Thus, PKM\u03b6 may represent a promising target for the treatment of chronic pain.\n                  <\/jats:p>","DOI":"10.1126\/science.1191792","type":"journal-article","created":{"date-parts":[[2010,12,2]],"date-time":"2010-12-02T14:40:36Z","timestamp":1291300836000},"page":"1400-1404","source":"Crossref","is-referenced-by-count":385,"title":["Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKM\u03b6 in the Anterior Cingulate Cortex"],"prefix":"10.1126","volume":"330","author":[{"given":"Xiang-Yao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada."},{"name":"Department of Brain and Cognitive Sciences, Seoul National University, Seoul 151 747, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung-Gon","family":"Ko","sequence":"additional","affiliation":[{"name":"National Creative 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