{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:12:37Z","timestamp":1791393157014,"version":"4.3.3"},"reference-count":25,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5991","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,7,30]]},"abstract":"<jats:title>Epithelial Cleft Formation<\/jats:title>\n                  <jats:p>\n                    The internal architecture of many embryonic organs is established by repetitive branching of epithelia. Epithelial clefts and outgrowths generate this internal branching of glands and other organs.\n                    <jats:bold>\n                      Onodera\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"562\" related-article-type=\"in-this-issue\" vol=\"329\" xlink:href=\"10.1126\/science.1191880\">562<\/jats:related-article>\n                    ) identify a gene,\n                    <jats:italic>Btbd7<\/jats:italic>\n                    , as a regulator of epithelial dynamics and cleft formation, linking the extracellular matrix with morphogenesis.\n                    <jats:italic>Btbd7<\/jats:italic>\n                    is induced by a matrix protein at sites of cleft progression and induces a transcription factor and suppresses cell adhesion. The resulting local cell separation and motility contribute to transient tissue gaps that contribute to clefts that help form branched organs.\n                  <\/jats:p>","DOI":"10.1126\/science.1191880","type":"journal-article","created":{"date-parts":[[2010,7,29]],"date-time":"2010-07-29T17:52:27Z","timestamp":1280425947000},"page":"562-565","source":"Crossref","is-referenced-by-count":136,"title":["Btbd7 Regulates Epithelial Cell Dynamics and Branching Morphogenesis"],"prefix":"10.1126","volume":"329","author":[{"given":"Tomohiro","family":"Onodera","sequence":"first","affiliation":[{"name":"Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892\u20134370, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Sakai","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892\u20134370, USA."},{"name":"Department of Oral-Facial Disorders, Osaka University Graduate School of Dentistry, Yamadaoka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff Chi-feng","family":"Hsu","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892\u20134370, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazue","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892\u20134370, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Chiorini","sequence":"additional","affiliation":[{"name":"Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892\u20134370, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Yamada","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892\u20134370, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10161"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5420.1635"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg840"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(03)00036-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.2006.00096.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr634"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2007.02.005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01089"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.2006.00088.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.22.010305.104340"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02310"},{"key":"e_1_3_2_13_2","first-page":"225","article-title":"Extracellular matrix involvement in epithelial branching morphogenesis","volume":"3","author":"Spooner B. 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