{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:39:19Z","timestamp":1792204759122,"version":"4.4.0"},"reference-count":27,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5999","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,9,24]]},"abstract":"<jats:title>Self-Renewing T Cells<\/jats:title>\n                  <jats:p>\n                    The homeostasis of cell populations within an organism can be achieved through a variety of mechanisms, including the differentiation of precursor populations, self-renewal of terminally differentiated cells, or by programming cells to be extremely long-lived. Regulatory T cells that express the transcription factor Foxp3 are critical for maintaining immune tolerance by preventing excessive inflammation and autoimmunity.\n                    <jats:bold>\n                      Rubtsov\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1667\" related-article-type=\"in-this-issue\" vol=\"329\" xlink:href=\"10.1126\/science.1191996\">1667<\/jats:related-article>\n                    ) now use genetic fate mapping and cell transfer studies in vivo to demonstrate that Foxp3-expressing cells are remarkably stable under both basal and inflammatory conditions. Thus, regulatory T cells appear to be maintained through self-renewal and should maintain their identity if used in adoptive cell therapies for treatment of autoimmunity or other inflammatory disorders.\n                  <\/jats:p>","DOI":"10.1126\/science.1191996","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T16:20:53Z","timestamp":1285258853000},"page":"1667-1671","source":"Crossref","is-referenced-by-count":684,"title":["Stability of the Regulatory T Cell Lineage in Vivo"],"prefix":"10.1126","volume":"329","author":[{"given":"Yuri P.","family":"Rubtsov","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Niec","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Josefowicz","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Darce","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Mathis","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Benoist","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Y.","family":"Rudensky","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20042"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02520"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni904"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.01.016"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(03)81008-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni909"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1428"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/ni816","article-title":"Origin of regulatory T cells with known specificity for antigen","volume":"3","author":"Apostolou I.","year":"2002","unstructured":"Apostolou I., Sarukhan A., Klein L., von Boehmer H., Origin of regulatory T cells with known specificity for antigen. 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