{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:00:04Z","timestamp":1790758804190,"version":"4.1.0"},"reference-count":24,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5999","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,9,24]]},"abstract":"<jats:title>Nervous Disposition<\/jats:title>\n                  <jats:p>\n                    Organ development requires the differentiation and coordination of nerves and blood vessels with multiple cell types. The peripheral parasympathetic nervous system innervates many organs during embryogenesis; however, the function of this interaction during organogenesis is unclear. By exploiting the close association during development of the parasympathetic ganglion with the mouse embryonic salivary gland epithelium,\n                    <jats:bold>\n                      Knox\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1645\" related-article-type=\"in-this-issue\" vol=\"329\" xlink:href=\"10.1126\/science.1192046\">1645<\/jats:related-article>\n                    ; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"5999\" page=\"1610\" related-article-type=\"in-this-issue\" vol=\"329\" xlink:href=\"10.1126\/science.1196016\">Rock and Hogan<\/jats:related-article>\n                    <\/jats:bold>\n                    ) found that neuronal innervation preserves an epithelial progenitor cell population via muscarinic receptor and epidermal growth factor receptor signaling. These progenitor cells are then maintained in the adult salivary gland. A similar system was observed in the developing prostate gland. Peripheral innervation is thus necessary for organogenesis and may also be involved in organ repair or regeneration.\n                  <\/jats:p>","DOI":"10.1126\/science.1192046","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T16:20:53Z","timestamp":1285258853000},"page":"1645-1647","source":"Crossref","is-referenced-by-count":297,"title":["Parasympathetic Innervation Maintains Epithelial Progenitor Cells During Salivary Organogenesis"],"prefix":"10.1126","volume":"329","author":[{"given":"S. M.","family":"Knox","sequence":"first","affiliation":[{"name":"Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. M. A.","family":"Lombaert","sequence":"additional","affiliation":[{"name":"Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Reed","sequence":"additional","affiliation":[{"name":"Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Vitale-Cross","sequence":"additional","affiliation":[{"name":"Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Gutkind","sequence":"additional","affiliation":[{"name":"Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162783"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80562-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063889"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064344"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03875"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.24.620.613"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2006.10.006"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(75)90136-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.2006.00088.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05537"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050847"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2461"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2623"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906850106"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104900214"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.6.1775"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2004-0197"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01690"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/47260"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.07.016"},{"key":"e_1_3_2_23_2","unstructured":"Hai B. et al. . 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