{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:53:56Z","timestamp":1791140036057,"version":"4.1.0"},"reference-count":18,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5995","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,8,27]]},"abstract":"<jats:title>Toward a General Flu Vaccination<\/jats:title>\n                  <jats:p>\n                    Current seasonal influenza virus vaccines are targeted against specific viral strains and do not provide broad, durable protection. Seasonal influenza vaccines induce protective antibody responses against regions of viral hemagglutinin (HA) that rapidly mutate so that very soon, the virus becomes resistant to vaccination. Conserved regions of HA also exist, and a major goal of influenza vaccine development is to design a vaccine that elicits antibodies against the conserved regions so that protection against a wide range of viral strains is achieved.\n                    <jats:bold>\n                      Wei\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1060\" related-article-type=\"in-this-issue\" vol=\"329\" xlink:href=\"10.1126\/science.1192517\">1060<\/jats:related-article>\n                    , published online 15 July; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"5995\" page=\"1021\" related-article-type=\"in-this-issue\" vol=\"329\" xlink:href=\"10.1126\/science.1195116\">Doms<\/jats:related-article>\n                    <\/jats:bold>\n                    ) show that a combined HA DNA prime, followed by boosting with a seasonal vaccine, elicits broadly cross-reactive neutralizing antibody responses in mice, ferrets, and nonhuman primates, which were protective in mice and ferrets against heterologous influenza challenge. The neutralizing antibodies were directed against the conserved HA stem region, which indicates the possibility that a more broadly protective vaccine against influenza could be developed.\n                  <\/jats:p>","DOI":"10.1126\/science.1192517","type":"journal-article","created":{"date-parts":[[2010,7,15]],"date-time":"2010-07-15T22:40:09Z","timestamp":1279233609000},"page":"1060-1064","source":"Crossref","is-referenced-by-count":296,"title":["Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination"],"prefix":"10.1126","volume":"329","author":[{"given":"Chih-Jen","family":"Wei","sequence":"first","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892\u20133005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Boyington","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892\u20133005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"McTamney","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892\u20133005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing-Pui","family":"Kong","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892\u20133005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa B.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xu","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892\u20133005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Andersen","sequence":"additional","affiliation":[{"name":"BIOQUAL, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Rao","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892\u20133005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence M.","family":"Tumpey","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yong","family":"Yang","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892\u20133005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Nabel","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892\u20133005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization \u201cAbout WHO Global Influenza Programme \u201d http:\/\/www.who.int\/csr\/disease\/influenza\/mission\/en\/ (2010)."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.5.2552-2558.1993"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171491"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1566"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801367105"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41902"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.13.8024-8031.2005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607564103"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"C. J. Wei et al. Cross-neutralization of 1918 and 2009 influenza viruses: Role of glycans in viral evolution and vaccine design. Sci. Transl. Med 2 24ra21 (2010).","DOI":"10.1126\/scitranslmed.3000799"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135165"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.7.6.783"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"G. Del Giudice et al. Seasonal influenza vaccine provides priming for A\/H1N1 immunization. Sci. Transl. Med 1 12re1 (2009).","DOI":"10.1126\/scitranslmed.3000564"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","unstructured":"S. Khurana et al. Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus. Sci. Transl. 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