{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:58:07Z","timestamp":1792166287273,"version":"4.4.0"},"reference-count":26,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5999","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,9,24]]},"abstract":"<jats:title>Enzymes for Sunscreen Synthesis<\/jats:title>\n                  <jats:p>\n                    Many fungi, cyanobacteria, algae, and other marine organisms can biosynthesize small molecules termed mycosporine and mycosporine-like amino acids (MAAs) that, among other functions, protect them from harmful UV exposure. A formulation containing MAAs is used as a sunscreen in skin care and cosmetic products.\n                    <jats:bold>Balskus and Walsh<\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1653\" related-article-type=\"in-this-issue\" vol=\"329\" xlink:href=\"10.1126\/science.1193637\">1653<\/jats:related-article>\n                    , published online 2 September) have now identified the gene cluster in a cyanobacterium that is responsible for MAA production. They expressed the cluster in\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and characterized the four biosynthetic enzymes bio chemically. Two are adenosine triphosphate.dependent peptide bond.forming enzymes that catalyze imine bond formation through unusual mechanisms.\n                  <\/jats:p>","DOI":"10.1126\/science.1193637","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T22:32:00Z","timestamp":1283466720000},"page":"1653-1656","source":"Crossref","is-referenced-by-count":357,"title":["The Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria"],"prefix":"10.1126","volume":"329","author":[{"given":"Emily P.","family":"Balskus","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0006323199005356"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1039\/a815159y"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.64.081501.155802"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2007.00650.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8817.1998.340418.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/212163a0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1139\/v76-158"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)91017-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8817.1998.340928.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002270000463"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/01490459709378046"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2004.08.016"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.06.004"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)83866-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2216\/i0031-8884-42-4-384.1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707388105"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2009.10.002"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2008.00376.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1515\/znc-1985-9-1004"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00445a009"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200600446"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/np070210q"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00206a059"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560061218"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr0503097"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(99)80082-9"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1193637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T08:53:44Z","timestamp":1704876824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1193637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,24]]},"references-count":26,"journal-issue":{"issue":"5999","published-print":{"date-parts":[[2010,9,24]]}},"alternative-id":["10.1126\/science.1193637"],"URL":"https:\/\/doi.org\/10.1126\/science.1193637","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.6110956.6142056","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,24]]}}}