{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:23:50Z","timestamp":1792005830163,"version":"4.4.0"},"reference-count":17,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6010","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,12,10]]},"abstract":"Muscle Building<\/jats:title>\n \n The signaling mechanisms involved in actin filament formation for myofibril formation, which is required for growth factor-induced muscle maturation and hypertrophy, remain unclear.\n \n Takano\n et al.<\/jats:italic>\n <\/jats:bold>\n (p.\n 1536<\/jats:related-article>\n ; see the Perspective by\n \n Gautel and Ehler<\/jats:bold>\n <\/jats:related-article>\n ) now show that the mechanism involves the interaction of nebulin and N-WASP. N-WASP is an activator of the Arp2\/3 complex, which induces branched actin filaments in nonmuscle cells. The nebulin\u2013N-WASP complex formed in muscle, however, causes nucleation of unbranched actin filaments within myofibrils without the Arp2\/3 complex. Nebulin\u2013N-WASP\u2013mediated myofibrillar actin filament formation is required for muscle hypertrophy and might explain a congenital hereditary neuromuscular disorder caused by nebulin gene mutation: nemaline myopathy.\n <\/jats:p>","DOI":"10.1126\/science.1197767","type":"journal-article","created":{"date-parts":[[2010,12,9]],"date-time":"2010-12-09T14:25:22Z","timestamp":1291904722000},"page":"1536-1540","source":"Crossref","is-referenced-by-count":82,"title":["Nebulin and N-WASP Cooperate to Cause IGF-1\u2013Induced Sarcomeric Actin Filament Formation"],"prefix":"10.1126","volume":"330","author":[{"given":"Kazunori","family":"Takano","sequence":"first","affiliation":[{"name":"Department of Biology, Graduate School of Science, Chiba University, 1-33 Yayoicho, Inageku, Chiba 263-8522, Japan."},{"name":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Chiyodaku, Tokyo 102-0075, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruko","family":"Watanabe-Takano","sequence":"additional","affiliation":[{"name":"Department of Biology, Graduate School of Science, Chiba University, 1-33 Yayoicho, Inageku, Chiba 263-8522, Japan."},{"name":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Chiyodaku, Tokyo 102-0075, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Suetsugu","sequence":"additional","affiliation":[{"name":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Chiyodaku, Tokyo 102-0075, Japan."},{"name":"Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032, Japan."},{"name":"Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Chiyodaku, Tokyo 102-0075, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souichi","family":"Kurita","sequence":"additional","affiliation":[{"name":"Department of Biology, Graduate School of Science, Chiba University, 1-33 Yayoicho, Inageku, Chiba 263-8522, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Tsujita","sequence":"additional","affiliation":[{"name":"Division of Lipid Biochemistry, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumiko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Biology, Graduate School of Science, Chiba University, 1-33 Yayoicho, Inageku, Chiba 263-8522, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Karatsu","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, 1-33 Yayoicho, Inageku, Chiba 263-8522, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadaomi","family":"Takenawa","sequence":"additional","affiliation":[{"name":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Chiyodaku, Tokyo 102-0075, Japan."},{"name":"Division of Lipid Biochemistry, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Biology, Graduate School of Science, Chiba University, 1-33 Yayoicho, Inageku, Chiba 263-8522, Japan."},{"name":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Chiyodaku, Tokyo 102-0075, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.biocel.2005.04.018","article-title":"Skeletal muscle hypertrophy and atrophy signaling pathways","volume":"37","author":"Glass D. 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