{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:23:59Z","timestamp":1789665839308,"version":"4.0.1"},"reference-count":9,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4216","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1975,11,21]]},"abstract":"<jats:p>Osteopetrosis was induced in lethally irradiated, normal mice of grey-lethal and microphthalmic stocks by cell infusions prepared from the spleens of osteopetrotic littermates. Failure of skeletal remodeling became evident within a few weeks after transplantation as calcified cartilage and bone accumulated excessively in the active metaphyses of the long bones. The massive lesions produced were extensively infiltrated with abnormal osteoclasts.<\/jats:p>","DOI":"10.1126\/science.1198094","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:11:22Z","timestamp":1160061082000},"page":"785-787","source":"Crossref","is-referenced-by-count":98,"title":["Spleen Cells Transmit Osteopetrosis in Mice"],"prefix":"10.1126","volume":"190","author":[{"given":"Donald G.","family":"Walker","sequence":"first","affiliation":[{"name":"Department of Anatomy, Johns Hopkins University, Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1177\/10.6.741","volume":"10","year":"1962","unstructured":"BARKA, T, HISTOCHEMICAL METHODS FOR ACID PHOSPHATASE USING HEXAZONIUM PARAROSANILIN AS COUPLER, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 10: 741 (1962).","journal-title":"JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY"},{"key":"e_1_2_1_2_1","first-page":"501","volume":"188","year":"1975","unstructured":"BARNES, DWH, HISTOCOMPATIBLE CELLS FOR RESOLUTION OF OSTEOPETROSIS IN MICROPHTHALMIC MICE, PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 188: 501 (1975).","journal-title":"PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/BF01900413","volume":"26","year":"1970","unstructured":"BEREK, L, OSSEAL CHANGES IN YOUNG MICE UNDERGOING GRAFT-VERSUS-HOST REACTION, EXPERIENTIA 26: 92 (1970).","journal-title":"EXPERIENTIA"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4051.793"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.185.4153.789"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/00003086-197311000-00025","volume":"97","year":"1973","unstructured":"WALKER, D.G., EXPERIMENTAL OSTEOPETROSIS, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH 97: 158 (1973).","journal-title":"CLINICAL ORTHOPAEDICS AND RELATED RESEARCH"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1210\/endo-91-4-916","volume":"91","year":"1972","unstructured":"WALKER, D.G., CONGENITAL OSTEOPETROSIS IN MICE CURED BY PARABIOTIC UNION WITH NORMAL SIBLINGS, ENDOCRINOLOGY 91: 916 (1972).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1084\/jem.142.3.651","volume":"142","year":"1975","unstructured":"WALKER, D.G., CONTROL OF BONE-RESORPTION BY HEMATOPOIETIC TISSUE - INDUCTION AND REVERSAL OF CONGENITAL OSTEOPETROSIS IN MICE THROUGH USE OF BONE-MARROW AND SPLENIC TRANSPLANTS, JOURNAL OF EXPERIMENTAL MEDICINE 142: 651 (1975).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.180.4088.875"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1198094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T14:59:11Z","timestamp":1704898751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1198094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,11,21]]},"references-count":9,"journal-issue":{"issue":"4216","published-print":{"date-parts":[[1975,11,21]]}},"alternative-id":["10.1126\/science.1198094"],"URL":"https:\/\/doi.org\/10.1126\/science.1198094","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,11,21]]}}}