{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:42:23Z","timestamp":1792716143061,"version":"4.5.0"},"reference-count":29,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6021","license":[{"start":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T00:00:00Z","timestamp":1295481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.sciencemag.org\/site\/feature\/contribinfo\/prep\/license.xhtml"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA121113"],"award-info":[{"award-number":["CA121113"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50CA062924"],"award-info":[{"award-number":["P50CA062924"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01CA134292"],"award-info":[{"award-number":["P01CA134292"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA113669"],"award-info":[{"award-number":["R01CA113669"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2011,3,4]]},"abstract":"<jats:p>A rare but deadly form of human pancreatic cancer harbors mutations in chromatin remodeling genes.<\/jats:p>","DOI":"10.1126\/science.1200609","type":"journal-article","created":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T22:53:51Z","timestamp":1295564031000},"page":"1199-1203","source":"Crossref","is-referenced-by-count":1579,"title":["<i>DAXX<\/i>\n                    \/\n                    <i>ATRX<\/i>\n                    ,\n                    <i>MEN1<\/i>\n                    , and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors"],"prefix":"10.1126","volume":"331","author":[{"given":"Yuchen","family":"Jiao","sequence":"first","affiliation":[{"name":"Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanjuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barish H.","family":"Edil","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roeland F.","family":"de Wilde","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Klimstra","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Maitra","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Schulick","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura H.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Wolfgang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Choti","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor E.","family":"Velculescu","sequence":"additional","affiliation":[{"name":"Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Luis A.","family":"Diaz","sequence":"additional","affiliation":[{"name":"Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA."},{"name":"Swim Across America Laboratory, Johns Hopkins University, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Vogelstein","sequence":"additional","affiliation":[{"name":"Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Kinzler","sequence":"additional","affiliation":[{"name":"Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph H.","family":"Hruban","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nickolas","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"R. H. Hruban M. B. Pitman D. S. Klimstra Tumors of the Pancreas Atlas of Tumor Pathology (American Registry of Pathology and Armed Forces Institute of Pathology Washington DC ed. 4 2007)."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-009-1776-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0734"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200310000-00012"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-10-0028"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.5858\/133.3.350"},{"key":"e_1_3_2_8_2","first-page":"3706","article-title":"Localization of putative tumor suppressor loci by genome-wide allelotyping in human pancreatic endocrine tumors","volume":"58","author":"Chung D. C.","year":"1998","unstructured":"Chung D. C., et al.., Localization of putative tumor suppressor loci by genome-wide allelotyping in human pancreatic endocrine tumors. Cancer Res. 58, 3706 (1998).9721882","journal-title":"Cancer Res."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2004.04.015"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947601910371979"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164368"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/436792a"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.05.008"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04869"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(04)00081-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.13.5639-5649.2004"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.172783"},{"key":"e_1_3_2_19_2","first-page":"6135","article-title":"Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex","volume":"63","author":"Kim H.","year":"2003","unstructured":"Kim H., Lee J. E., Cho E. J., Liu J. O., Youn H. D., Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex. Cancer Res. 63, 6135 (2003).14559791","journal-title":"Cancer Res."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80967-8"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008850107"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20734"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.566910"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.003"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.101477.109"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.09.023"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.5988"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64624-X"},{"key":"e_1_3_2_29_2","unstructured":"J. C. Yao et al. Ann. Oncol. 21 (suppl. 8) viii4 (2010)."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2926"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001671"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1200609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T10:06:28Z","timestamp":1704881188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1200609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,4]]},"references-count":29,"journal-issue":{"issue":"6021","published-print":{"date-parts":[[2011,3,4]]}},"alternative-id":["10.1126\/science.1200609"],"URL":"https:\/\/doi.org\/10.1126\/science.1200609","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.7979956.8354055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.7979956.10473054","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,4]]}}}