{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:42:41Z","timestamp":1792676561614,"version":"4.5.0"},"reference-count":21,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6064","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,1,6]]},"abstract":"<jats:title>From Nucleoside Recycling to Histiocytosis<\/jats:title>\n                  <jats:p>\n                    Macrophages remove billions of apoptotic cells daily, releasing their nucleic acid material through lysosomal degradation, which allows the resulting nucleosides to be recycled.\n                    <jats:bold>\n                      Hsu\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"89\" related-article-type=\"in-this-issue\" vol=\"335\" xlink:href=\"10.1126\/science.1213682\">89<\/jats:related-article>\n                    , published online 15 December) found that the nucleoside transporter, equilibrative nucleoside transporter 3 (ENT3), was highly expressed in macrophages and showed that mice deficient in this transporter develop histiocytosis and features of lysosomal storage disease. When exposed to apoptotic cells, macrophages carrying human ENT3 mutations accumulated adenosine and increased their lysosomal pH. These changes contributed to an enhanced signaling through macrophage colony-stimulating factor (M-CSF) receptor and, ultimately, to M-CSF\u2013driven myeloproliferative disease.\n                  <\/jats:p>","DOI":"10.1126\/science.1213682","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T01:16:49Z","timestamp":1323998209000},"page":"89-92","source":"Crossref","is-referenced-by-count":141,"title":["Equilibrative Nucleoside Transporter 3 Deficiency Perturbs Lysosome Function and Macrophage Homeostasis"],"prefix":"10.1126","volume":"335","author":[{"given":"Chia-Lin","family":"Hsu","sequence":"first","affiliation":[{"name":"Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, 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