{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:10:07Z","timestamp":1791677407592,"version":"4.3.4"},"reference-count":61,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6078","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,4,13]]},"abstract":"<jats:title>Disrupting Drug Memories<\/jats:title>\n                  <jats:p>\n                    In drug recovery programs, conditioned responses to drug cues can be inhibited by extinction protocols. However, extinguished behavioral responses can return after renewed exposure to the drug itself, or to drug-associated paraphernalia, and sometimes these responses reemerge spontaneously. Attempts have been made to disrupt cue-memory reconsolidation or to strengthen extinction learning, but these efforts have often relied on pharmacological agents that either are not approved for human use or cause problematic side effects.\n                    <jats:bold>\n                      Xue\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"241\" related-article-type=\"in-this-issue\" vol=\"336\" xlink:href=\"10.1126\/science.1215070\">241<\/jats:related-article>\n                    ; see the Perspective by\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6078\" page=\"167\" related-article-type=\"in-this-issue\" vol=\"336\" xlink:href=\"10.1126\/science.1221691\">\n                      <jats:bold>Milton and Everitt<\/jats:bold>\n                    <\/jats:related-article>\n                    ) have tried to circumvent the limitations of pharmacological approaches in daily retrieval trials conducted in rats within the short timeframe of the \u201creconsolidation window\u201d before the extinction sessions reduced drug-induced reinstatement, spontaneous recovery, and renewal of drug seeking. When translated to heroin-addicted humans, similar retrieval trials before extinction sessions impaired cue-induced heroin craving up to 6 months later. This retrieval-extinction procedure is thus a promising non-pharmacological treatment for addiction.\n                  <\/jats:p>","DOI":"10.1126\/science.1215070","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T14:14:39Z","timestamp":1334240079000},"page":"241-245","source":"Crossref","is-referenced-by-count":462,"title":["A Memory Retrieval-Extinction Procedure to Prevent Drug Craving and Relapse"],"prefix":"10.1126","volume":"336","author":[{"given":"Yan-Xue","family":"Xue","sequence":"first","affiliation":[{"name":"National Institute on Drug Dependence, Peking University, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xiao","family":"Luo","sequence":"additional","affiliation":[{"name":"National Institute on Drug Dependence, Peking University, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"National Institute on Drug Dependence, Peking University, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Shui","family":"Shi","sequence":"additional","affiliation":[{"name":"National Institute on Drug Dependence, Peking University, Beijing 100191, China."},{"name":"Department of Biochemistry and Molecular Biology, Basic Medical College, Hebei Medical University, Shijiazhuang 050017, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Fen","family":"Xue","sequence":"additional","affiliation":[{"name":"National Institute on Drug Dependence, Peking University, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"National Institute on Drug Dependence, Peking University, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Institute on Drug Dependence, Peking University, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng-Bo","family":"Ding","sequence":"additional","affiliation":[{"name":"National Institute on Drug Dependence, Peking University, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-ping","family":"Bao","sequence":"additional","affiliation":[{"name":"National Institute on Drug Dependence, Peking University, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shi","sequence":"additional","affiliation":[{"name":"National Institute on Drug Dependence, Peking University, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Epstein","sequence":"additional","affiliation":[{"name":"Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavin","family":"Shaham","sequence":"additional","affiliation":[{"name":"Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"National Institute on Drug Dependence, Peking University, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"C. P. O\u2019Brien R. N. Ehrman J. W. Ternes in Behavioral Analysis of Drug Dependence S. Goldberg I. Stolerman Eds. (Academic Press Orlando FL 1986) pp. 329\u2013356."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.91.2.251"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4603(90)90048-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2002.00014.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01546-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2090"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07249.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.007"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03974.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/35021052"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2006.03.010"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.11.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.825008"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2010.00179"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2112-10.2010"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3149-09.2010"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4818-05.2006"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0323-06.2006"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1167975"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08637"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1224-x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(91)90091-8"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0090"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","unstructured":"R. E. See Eur. J. Pharmacol. 526 140 (2005).","DOI":"10.1001\/archsurg.140.6.526"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432175"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.1.1"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050256"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.116.1.169"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2949"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1144334"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.63"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5884-10.2011"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000499"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086881"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/35044580"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.03.010"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2590"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195298"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.2148511"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1912510"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.84904"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0019582"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.084"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301555"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1041309"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.07.027"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0750-08.2008"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(94)00021-R"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04071"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1054608"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00239-4"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1383"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.04.011"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3027-08.2008"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1860-4"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-05-01957.1996"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0023-9690(79)90057-2"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1089\/cpb.2008.0032"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1159\/000097968"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1993.tb01026.x"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2010.05.010"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1215070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T10:36:16Z","timestamp":1704882976000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1215070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,13]]},"references-count":61,"journal-issue":{"issue":"6078","published-print":{"date-parts":[[2012,4,13]]}},"alternative-id":["10.1126\/science.1215070"],"URL":"https:\/\/doi.org\/10.1126\/science.1215070","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.14267421.15779656","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,13]]}}}