{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:59:38Z","timestamp":1792033178019,"version":"4.4.0"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6083","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,5,18]]},"abstract":"<jats:title>An Aspirin a Day?<\/jats:title>\n                  <jats:p>\n                    The protein kinase AMPK (adenosine monophosphate\u2013activated protein kinase) directly monitors cellular energy stores as reflected by changes in cellular concentrations of AMP, adenosine diphosphate (ADP), and adenosine triphosphate (ATP). Through phosphorylation of its targets, it helps to control metabolism, polarity, autophagy, and the restraint of cell proliferation. Activation of AMPK is also proposed to be beneficial for the treatment of diseases, including cancer and diabetes.\n                    <jats:bold>\n                      Hawley\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"918\" related-article-type=\"in-this-issue\" vol=\"336\" xlink:href=\"10.1126\/science.1215327\">918<\/jats:related-article>\n                    , published online 19 April; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6083\" page=\"813\" related-article-type=\"in-this-issue\" vol=\"336\" xlink:href=\"10.1126\/science.1223140\">Shaw and Cantley<\/jats:related-article>\n                    <\/jats:bold>\n                    ) report that AMPK can be activated by high concentrations of salicylate, a compound derived from the very commonly used drug aspirin. In mice, salicylate promoted fatty acid and carbohydrate metabolism in an AMPK-dependent fashion.\n                  <\/jats:p>","DOI":"10.1126\/science.1215327","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T20:44:55Z","timestamp":1334954695000},"page":"918-922","source":"Crossref","is-referenced-by-count":674,"title":["The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase"],"prefix":"10.1126","volume":"336","author":[{"given":"Simon A.","family":"Hawley","sequence":"first","affiliation":[{"name":"Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan D.","family":"Fullerton","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Metabolism, Department of Medicine, and Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Schertzer","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Metabolism, Department of Medicine, and Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Chevtzoff","sequence":"additional","affiliation":[{"name":"Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Walker","sequence":"additional","affiliation":[{"name":"Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Peggie","sequence":"additional","affiliation":[{"name":"Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darya","family":"Zibrova","sequence":"additional","affiliation":[{"name":"Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Green","sequence":"additional","affiliation":[{"name":"Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty J.","family":"Mustard","sequence":"additional","affiliation":[{"name":"Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce E.","family":"Kemp","sequence":"additional","affiliation":[{"name":"St. Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic 3065 Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Metabolism, Department of Medicine, and Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada."},{"name":"St. Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic 3065 Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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