{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:57:22Z","timestamp":1791295042186,"version":"4.1.0"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6066","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,1,20]]},"abstract":"<jats:title>Natural Killer Controls<\/jats:title>\n                  <jats:p>\n                    Cytolytic natural killer (NK) cells participate in both antimicrobial and antitumor immunity. Their responsiveness is tuned through signals received through a variety of inhibitory and activating receptors expressed on their cell surface.\n                    <jats:bold>\n                      Narni-Mancinelli\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"344\" related-article-type=\"in-this-issue\" vol=\"335\" xlink:href=\"10.1126\/science.1215621\">344<\/jats:related-article>\n                    ) now show that signaling through the activating receptor NKp46 paradoxically keeps NK cell responses in check. NK cells from mice with disrupted NKp46 expression were hyperresponsive to stimulation and better protected against viral infection. NK cell responses, which are part of the early response to infection, may thus need to be carefully tuned to ensure optimal initiation of adaptive immunity and formation of protective long-lived memory cells.\n                  <\/jats:p>","DOI":"10.1126\/science.1215621","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T14:12:54Z","timestamp":1326982374000},"page":"344-348","source":"Crossref","is-referenced-by-count":187,"title":["Tuning of Natural Killer Cell Reactivity by NKp46 and Helios Calibrates T Cell Responses"],"prefix":"10.1126","volume":"335","author":[{"given":"Emilie","family":"Narni-Mancinelli","sequence":"first","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Aix-Marseille University, Campus de Luminy case 906, 13288 Marseille, France."},{"name":"INSERM U1104, 13288 Marseille, France."},{"name":"CNRS, UMR7280, 13288 Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste 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