{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:46:37Z","timestamp":1791351997493,"version":"4.3.1"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6067","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,1,27]]},"abstract":"<jats:title>Prion Problem<\/jats:title>\n          <jats:p>\n            Prion disease, like \u201cmad cow disease,\u201d has shown a frightening ability to cross the species transmission barrier, but, mercifully, with low efficiency. However, the role of different tissues in prion cross-species transmission is unclear.\n            <jats:bold>\n              B\u00e9ringue\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"472\" related-article-type=\"in-this-issue\" vol=\"335\" xlink:href=\"10.1126\/science.1215659\">472<\/jats:related-article>\n            ; see the cover; see the Perspective by\n            <jats:bold>\n              <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6067\" page=\"411\" related-article-type=\"in-this-issue\" vol=\"335\" xlink:href=\"10.1126\/science.1218167\">Collinge<\/jats:related-article>\n            <\/jats:bold>\n            ) compared the ability of brain and lymphoid tissues from \u201covinized\u201d (sheeplike) and \u201chumanized\u201d transgenic mouse models to replicate prion transmission across a robust transmission barrier. Lymphoid tissue of these mice was consistently more permissive than brain tissue to prions such as those causing chronic wasting disease and bovine spongiform encephalopathy. Because previous measures of the transmission barrier have focused on the brain, this heightened susceptibility of lymphoid tissues could strongly impact estimates of the number of silent carriers of prion disease.\n          <\/jats:p>","DOI":"10.1126\/science.1215659","type":"journal-article","created":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T19:27:18Z","timestamp":1327606038000},"page":"472-475","source":"Crossref","is-referenced-by-count":141,"title":["Facilitated Cross-Species Transmission of Prions in Extraneural Tissue"],"prefix":"10.1126","volume":"335","author":[{"given":"Vincent","family":"B\u00e9ringue","sequence":"first","affiliation":[{"name":"Institut National de la Recherche Agronomique (INRA), UR892, Virologie Immunologie Mol\u00e9culaires, B\u00e2timent 440, F-78350 Jouy-en-Josas, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00ebtitia","family":"Herzog","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique (INRA), UR892, Virologie Immunologie Mol\u00e9culaires, B\u00e2timent 440, F-78350 Jouy-en-Josas, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Jaumain","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique (INRA), UR892, Virologie Immunologie Mol\u00e9culaires, B\u00e2timent 440, F-78350 Jouy-en-Josas, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Reine","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique (INRA), UR892, Virologie Immunologie Mol\u00e9culaires, B\u00e2timent 440, F-78350 Jouy-en-Josas, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sibille","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique (INRA), UR892, Virologie Immunologie Mol\u00e9culaires, B\u00e2timent 440, F-78350 Jouy-en-Josas, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Le Dur","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique (INRA), UR892, Virologie Immunologie Mol\u00e9culaires, B\u00e2timent 440, F-78350 Jouy-en-Josas, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Vilotte","sequence":"additional","affiliation":[{"name":"INRA, UMR1313, G\u00e9n\u00e9tique Animale et Biologie Int\u00e9grative, F-78350 Jouy-en-Josas, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Laude","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique (INRA), UR892, Virologie Immunologie Mol\u00e9culaires, B\u00e2timent 440, F-78350 Jouy-en-Josas, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13363"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.519"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2204"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-234-2_17"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2008024"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138718"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.182.4107.67"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020012"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103932"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf653"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0693-07.2007"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001419"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030031"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.12.9032-9044.1997"},{"key":"e_1_3_2_16_2","first-page":"37","article-title":"Pathogenesis of experimental scrapie","volume":"135","author":"Kimberlin R. 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