{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:09:55Z","timestamp":1792004995094,"version":"4.4.0"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6080","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,4,27]]},"abstract":"<jats:title>Generating Inflammasomes<\/jats:title>\n          <jats:p>\n            Inflammasomes are large, multiprotein complexes that assemble in response to infection that are also involved in the pathogenesis of a variety of other diseases, including type 2 diabetes and atherosclerosis. The assembly of the inflammasome triggers an inflammatory cascade that results in the activation of caspase-1 and production of the cytokines interleukin-1 and -18. Very little, however, is known about the specific signals that trigger inflammasome assembly.\n            <jats:bold>\n              Shenoy\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p. 481, published online 29 March; see the Perspective by\n            <jats:bold>\n              <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6080\" page=\"420\" related-article-type=\"in-this-issue\" vol=\"336\" xlink:href=\"10.1126\/science.1222362\">Caffrey and Fitzgerald<\/jats:related-article>\n            <\/jats:bold>\n            ) now show that guanylate binding protein 5 (GBP5) promotes the assembly of the NLRP3-containing inflammasome in response to certain activation signals, such as pathogenic bacteria and adenosine triphosphate, but not others, like crystalline stimuli. Mice deficient in GBP5 exhibited impaired caspase-1 activation and production of cytokines. NLRP3 inflammasome\u2013dependent responses to pathogenic bacteria and inflammatory stimuli were also impaired in mice lacking GBP5.\n          <\/jats:p>","DOI":"10.1126\/science.1217141","type":"journal-article","created":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T06:22:23Z","timestamp":1333088543000},"page":"481-485","source":"Crossref","is-referenced-by-count":504,"title":["GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals"],"prefix":"10.1126","volume":"336","author":[{"given":"Avinash R.","family":"Shenoy","sequence":"first","affiliation":[{"name":"Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wellington","sequence":"additional","affiliation":[{"name":"Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, 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