{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:05:16Z","timestamp":1792199116580,"version":"4.4.0"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6085","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>The Real McCoy<\/jats:title>\n                  <jats:p>\n                    Some secreted proteins are phosphorylated, the most prominent example being the milk protein casein, but the enzymes that catalyze such phosphorylation have not been identified. (The proteins known as \u201ccasein kinases\u201d are in fact cytosolic proteins and do not mediate physiological phosphorylation of casein.)\n                    <jats:bold>\n                      Tagliabracci\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1150\" related-article-type=\"in-this-issue\" vol=\"336\" xlink:href=\"10.1126\/science.1217817\">1150<\/jats:related-article>\n                    , published online 10 May) searched for a human protein with the characteristics expected of a secretory protein kinase and identified Fam20C. Mutations in the gene encoding Fam20C cause defects in bone formation. Furthermore, the consensus sequence for Fam20C phosphorylation was found in several secreted proteins that function in biomineralization. Thus, Fam20C appears to be the \u201creal\u201d casein kinase and to function in bone physiology.\n                  <\/jats:p>","DOI":"10.1126\/science.1217817","type":"journal-article","created":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T00:46:28Z","timestamp":1336697188000},"page":"1150-1153","source":"Crossref","is-referenced-by-count":454,"title":["Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization"],"prefix":"10.1126","volume":"336","author":[{"given":"Vincent S.","family":"Tagliabracci","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093\u20130721, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093\u20130721, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093\u20130721, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E.","family":"Wiley","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093\u20130721, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn A.","family":"Worby","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093\u20130721, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa N.","family":"Kinch","sequence":"additional","affiliation":[{"name":"University of Texas, Southwestern Medical Center, Dallas, TX 75390\u20139050, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093\u20130721, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick V.","family":"Grishin","sequence":"additional","affiliation":[{"name":"University of Texas, Southwestern Medical Center, Dallas, TX 75390\u20139050, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD 20815\u20136789, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack E.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093\u20130721, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD 20815\u20136789, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0502-e127"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac800835y"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr900603n"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr900780s"},{"key":"e_1_3_2_6_2","first-page":"227","article-title":"Zur Frage ob Case\u00edn ein einheitlicher Stoff sei","volume":"7","author":"Hammarsten O.","year":"1883","unstructured":"Hammarsten O., Zur Frage ob Case\u00edn ein einheitlicher Stoff sei. 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