{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:51:45Z","timestamp":1791474705970,"version":"4.3.4"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6079","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,4,20]]},"abstract":"<jats:title>A Specific Oxidative Catastrophe<\/jats:title>\n                  <jats:p>\n                    Three different classes of antibiotics induce bacterial cell death by the production of hydroxyl radicals. Hydroxyl radicals are powerful oxidizing agents in living cells and will oxidize the nucleic acid base, guanine, to form 8-oxoguanine, which is potentially mutagenic because it can pair with both cytosine and adenine and form lethal double-strand DNA breaks.\n                    <jats:bold>\n                      Foti\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"315\" related-article-type=\"in-this-issue\" vol=\"336\" xlink:href=\"10.1126\/science.1219192\">315<\/jats:related-article>\n                    ) discovered that overproduction of the nucleotide sanitizer MutT, which hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, gives striking protection against cell death.\n                  <\/jats:p>","DOI":"10.1126\/science.1219192","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T14:30:17Z","timestamp":1334845817000},"page":"315-319","source":"Crossref","is-referenced-by-count":466,"title":["Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics"],"prefix":"10.1126","volume":"336","author":[{"given":"James J.","family":"Foti","sequence":"first","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babho","family":"Devadoss","sequence":"additional","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Winkler","sequence":"additional","affiliation":[{"name":"Program in Molecular Biology, Cell Biology, and Biochemistry, Boston University, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Collins","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Biomedical Engineering, and Center for BioDynamics, Boston University, Boston, MA 02215, USA."},{"name":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02118, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham C.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.049"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.11.024"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06423.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901403106"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2834821"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.4.1171"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.1016\/S0021-9258(19)68927-1","article-title":"Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical","volume":"256","author":"Repine J. E.","year":"1981","unstructured":"Repine J. E., Fox R. B., Berger E. M., Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical. J. Biol. Chem. 256, 7094 (1981).6265438","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1128\/jb.177.9.2305-2314.1995","article-title":"Lethal oxidative damage and mutagenesis are generated by iron in delta fur mutants of Escherichia coli: Protective role of superoxide dismutase","volume":"177","author":"Touati D.","year":"1995","unstructured":"Touati D., Jacques M., Tardat B., Bouchard L., Despied S., Lethal oxidative damage and mutagenesis are generated by iron in delta fur mutants of Escherichia coli: Protective role of superoxide dismutase. J. Bacteriol. 177, 2305 (1995).7730258","journal-title":"J. Bacteriol."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.05.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx0600043"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp1095"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04318"},{"key":"e_1_3_2_14_2","unstructured":"E. C. Friedberg et al . DNA Repair and Mutagenesis (American Society for Microbiology Washington DC ed. 2 2005)."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200965200"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn062"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00776-07"},{"key":"e_1_3_2_18_2","first-page":"105","article-title":"Radiation and hydrogen peroxide induced free radical damage to DNA","volume":"8","author":"Ward J. F.","year":"1987","unstructured":"Ward J. F., Evans J. W., Limoli C. L., Calabro-Jones P. M., Radiation and hydrogen peroxide induced free radical damage to DNA. Br. J. Cancer Suppl. 8, 105 (1987).2820457","journal-title":"Br. J. Cancer Suppl."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553009214551591"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2307\/3574108"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/embo-reports\/kvd109","article-title":"The beta clamp targets DNA polymerase IV to DNA and strongly increases its processivity","volume":"1","author":"Wagner J.","year":"2000","unstructured":"Wagner J., Fujii S., Gruz P., Nohmi T., Fuchs R. P., The beta clamp targets DNA polymerase IV to DNA and strongly increases its processivity. EMBO Rep. 1, 484 (2000).11263491","journal-title":"EMBO Rep."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.26.18201"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/381972"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/35021219"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1656(97)01681-7"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.41.26394"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2004.07.010"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.1087"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1093\/genetics\/134.4.1023","article-title":"Mutants of Escherichia coli with increased fidelity of DNA replication","volume":"134","author":"Fijalkowska I. J.","year":"1993","unstructured":"Fijalkowska I. J., Dunn R. L., Schaaper R. M., Mutants of Escherichia coli with increased fidelity of DNA replication. Genetics 134, 1023 (1993).8375645","journal-title":"Genetics"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.038"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5335.128"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi047550k"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.100422497"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02536.x"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21797"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.01.003"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/472032a"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2115"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/dsi012"},{"key":"e_1_3_2_40_2","unstructured":"M. Inouye Experimental Manipulation of Gene Expression (Academic Press New York 1983)."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi701328h"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.115774"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100135"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050008"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.2.185"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/2241164a0"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.01.012"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04318"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100050"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1219192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T08:39:14Z","timestamp":1704875954000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1219192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,20]]},"references-count":48,"journal-issue":{"issue":"6079","published-print":{"date-parts":[[2012,4,20]]}},"alternative-id":["10.1126\/science.1219192"],"URL":"https:\/\/doi.org\/10.1126\/science.1219192","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.713997951.790052862","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.713997951.791902833","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.713997951.791952811","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.713997951.789452901","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,20]]}}}