{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:02:56Z","timestamp":1793422976114,"version":"4.5.0"},"reference-count":42,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6079","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,4,20]]},"abstract":"<jats:title>Thoroughly MODern Yeast<\/jats:title>\n          <jats:p>\n            It is not clear if prion induction in yeast is truly linked to physiological roles.\n            <jats:bold>\n              Suzuki\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"355\" related-article-type=\"in-this-issue\" vol=\"336\" xlink:href=\"10.1126\/science.1219491\">355<\/jats:related-article>\n            ) show that the yeast prion protein Mod5 (a transfer RNA isopentenyltransferase) responds to an environmental stressor by converting to an aggregated amyloid form, which leads to phenotypic changes in cell metabolism and drug resistance. Introduction of Mod5 amyloid into yeast resulted in the formation of a dominantly heritable prion state [\n            <jats:italic>MOD<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            ], in which Mod5 is aggregated. [\n            <jats:italic>MOD<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            ] yeast showed high ergosterol levels and acquired resistance to several antifungal agents. Selective pressure by antifungal drugs on nonprion [\n            <jats:italic>mod<\/jats:italic>\n            <jats:sup>\u2212<\/jats:sup>\n            ] yeast induced the [\n            <jats:italic>MOD<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            ] prion state, formation of amyloid, and increased cell survival.\n          <\/jats:p>","DOI":"10.1126\/science.1219491","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T18:30:17Z","timestamp":1334860217000},"page":"355-359","source":"Crossref","is-referenced-by-count":222,"title":["A Yeast Prion, Mod5, Promotes Acquired Drug Resistance and Cell Survival Under Environmental Stress"],"prefix":"10.1126","volume":"336","author":[{"given":"Genjiro","family":"Suzuki","sequence":"first","affiliation":[{"name":"Laboratory for Protein Conformation Diseases, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Shimazu","sequence":"additional","affiliation":[{"name":"Laboratory for Protein Conformation Diseases, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motomasa","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Laboratory for Protein Conformation Diseases, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7909170"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.072199199"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3007"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504882102"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2004.09.002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.044"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/35035005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02885"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1708"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060294"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191081"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00427-5"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.112"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1843"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.10.069"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600772"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020086"},{"key":"e_1_3_2_20_2","first-page":"177","article-title":"Isolation and characterization of MOD5, a gene required for isopentenylation of cytoplasmic and mitochondrial tRNAs of Saccharomyces cerevisiae","volume":"7","author":"Dihanich M. 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