{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:34:24Z","timestamp":1791333264169,"version":"4.3.1"},"reference-count":19,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6091","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,7,13]]},"abstract":"MMS19 Joins the CIA<\/jats:title>\n \n Iron-sulfur (Fe-S) proteins play a critical role in cell metabolism and particularly in DNA repair and replication. Mutants in eukaryotic gene\n MMS19<\/jats:italic>\n are particularly sensitive to DNA damaging agents, suggesting that it is involved in DNA repair, but the mutations can also have other wide-ranging effects on the cell (see the Perspective by\n \n Gottschling<\/jats:related-article>\n <\/jats:bold>\n ). Now,\n \n Stehling\n et al.<\/jats:italic>\n <\/jats:bold>\n (p.\n 195<\/jats:related-article>\n , published online 7 June) and\n \n Gari\n et al.<\/jats:italic>\n <\/jats:bold>\n (p.\n 243<\/jats:related-article>\n , published online 7 June) show that in both yeast and humans, MMS19 functions as part of the cytosolic Fe-S protein assembly (CIA) machinery. The MMS19 is part of a specialized CIA targeting complex that plays a role late in cytosolic Fe-S protein assembly to direct Fe-S cluster transfer from the CIA scaffold complex to a subset of Fe-S proteins, including a number associated with DNA metabolism.\n <\/jats:p>","DOI":"10.1126\/science.1219664","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T23:12:35Z","timestamp":1339110755000},"page":"243-245","source":"Crossref","is-referenced-by-count":230,"title":["MMS19 Links Cytoplasmic Iron-Sulfur Cluster Assembly to DNA Metabolism"],"prefix":"10.1126","volume":"337","author":[{"given":"Kerstin","family":"Gari","sequence":"first","affiliation":[{"name":"DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Le\u00f3n Ortiz","sequence":"additional","affiliation":[{"name":"DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Borel","sequence":"additional","affiliation":[{"name":"DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Flynn","sequence":"additional","affiliation":[{"name":"Protein Analysis and Proteomics Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Mark","family":"Skehel","sequence":"additional","affiliation":[{"name":"Protein Analysis and Proteomics Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Boulton","sequence":"additional","affiliation":[{"name":"DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333097"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.12.6783"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710736105"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.22.4506"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.07.029"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10161"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.016"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.05.026"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183112"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.07.019"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.721"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1288"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808526200"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08301"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09472"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.39"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.24.10833-10841.2005"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-003-0407-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.04.014"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1219664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T10:39:55Z","timestamp":1704883195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1219664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,13]]},"references-count":19,"journal-issue":{"issue":"6091","published-print":{"date-parts":[[2012,7,13]]}},"alternative-id":["10.1126\/science.1219664"],"URL":"https:\/\/doi.org\/10.1126\/science.1219664","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717953751.793459352","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,13]]}}}