{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:21:49Z","timestamp":1791411709233,"version":"4.3.3"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6089","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,6,29]]},"abstract":"<jats:title>Alkaloid Synthetic Pathway<\/jats:title>\n                  <jats:p>\n                    Noscapine, a nonaddictive alkaloid found in the opium poppy, can be used as a cough suppressant and a tubulin-binding antitumor agent.\n                    <jats:bold>\n                      Winzer\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1704\" related-article-type=\"in-this-issue\" vol=\"336\" xlink:href=\"10.1126\/science.1220757\">1704<\/jats:related-article>\n                    , published online 31 May; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6089\" page=\"1648\" related-article-type=\"in-this-issue\" vol=\"336\" xlink:href=\"10.1126\/science.1225473\">DellaPenna and O'Connor<\/jats:related-article>\n                    <\/jats:bold>\n                    ) found that a cluster of 10 genes were key to the production of noscapine. Poppies homozygous for this gene cluster produced high levels of noscapine, heterozygous poppies produced low levels of noscapine, and those poppies lacking the gene cluster produced no noscapine. Silencing individual genes in turn and analyzing the accumulation of intermediate metabolites allowed the biosynthetic pathway of noscapine to be elucidated.\n                  <\/jats:p>","DOI":"10.1126\/science.1220757","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:14:27Z","timestamp":1338509667000},"page":"1704-1708","source":"Crossref","is-referenced-by-count":321,"title":["A\n                    <i>Papaver somniferum<\/i>\n                    10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine"],"prefix":"10.1126","volume":"336","author":[{"given":"Thilo","family":"Winzer","sequence":"first","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Gazda","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhesi","family":"He","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Kern","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony R.","family":"Larson","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus","family":"Meade","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Teodor","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabi\u00e1n E.","family":"Vaistij","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Walker","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, 1061 Mountain Highway, PO Box 168, Boronia, VIC 3155, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim A.","family":"Bowser","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, 1061 Mountain Highway, PO Box 168, Boronia, VIC 3155, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Graham","sequence":"additional","affiliation":[{"name":"Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"275","article-title":"Observations sur le m\u00e9moire de M. 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