{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:46:32Z","timestamp":1792104392548,"version":"4.4.0"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6098","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,8,31]]},"abstract":"<jats:title>From Farm to Clinic?<\/jats:title>\n                  <jats:p>\n                    Soil organisms have long been assumed to be an important source of antibiotic resistance genes, in part because of antibiotic-treated livestock and in part because of the natural ecology of antibiotic production in the soil.\n                    <jats:bold>\n                      Forsberg\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1107\" related-article-type=\"in-this-issue\" vol=\"337\" xlink:href=\"10.1126\/science.1220761\">1107<\/jats:related-article>\n                    ) developed a metagenomic protocol to assemble short-read sequence data after antibiotic selection experiments, using 12 different drugs in all antibiotic classes, and compared antibiotic resistance gene sequences between soil bacteria and clinically occurring pathogens. Sixteen sequences, representing seven gene products, were discovered in farmland soil bacteria within long stretches of perfect nucleotide identity with pathogenic proteobacteria.\n                  <\/jats:p>","DOI":"10.1126\/science.1220761","type":"journal-article","created":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T14:17:34Z","timestamp":1346336254000},"page":"1107-1111","source":"Crossref","is-referenced-by-count":1518,"title":["The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens"],"prefix":"10.1126","volume":"337","author":[{"given":"Kevin J.","family":"Forsberg","sequence":"first","affiliation":[{"name":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Reyes","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA."},{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Selleck","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten O. 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