{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:14:44Z","timestamp":1790687684678,"version":"4.1.0"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6101","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,9,21]]},"abstract":"<jats:title>What Kitty Shares with Kings<\/jats:title>\n          <jats:p>\n            Although long-studied, the underlying basis of mammalian coat patterns remains unclear. By studying a large number of cat species and varieties,\n            <jats:bold>\n              Kaelin\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1536\" related-article-type=\"in-this-issue\" vol=\"337\" xlink:href=\"10.1126\/science.1220893\">1536<\/jats:related-article>\n            ) identified two genes,\n            <jats:italic>Taqpep<\/jats:italic>\n            and\n            <jats:italic>Edn3<\/jats:italic>\n            , as critical factors in the development of feline pigment patterns. Mutations in\n            <jats:italic>Taqpep<\/jats:italic>\n            are responsible for the blotched tabby pattern in domestic cats and the unusual coat of wild king cheetahs. Gene expression patterns in cat and cheetah skin suggest that\n            <jats:italic>Edn3<\/jats:italic>\n            is a likely regulator of felid hair color. The findings support a common model for coat and pigment pattern formation in domestic and wild cats.\n          <\/jats:p>","DOI":"10.1126\/science.1220893","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T18:16:28Z","timestamp":1348164988000},"page":"1536-1541","source":"Crossref","is-referenced-by-count":131,"title":["Specifying and Sustaining Pigmentation Patterns in Domestic and Wild Cats"],"prefix":"10.1126","volume":"337","author":[{"given":"Christopher B.","family":"Kaelin","sequence":"first","affiliation":[{"name":"HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA."},{"name":"Department of Genetics, Stanford University, Stanford, CA, 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Laboratory of Genomic Diversity, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA."},{"name":"Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife, College of Life Sciences, Sichuan University, Sichuan 610064, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis Z.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University, Stanford, CA, 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor A.","family":"David","sequence":"additional","affiliation":[{"name":"Laboratory of Genomic Diversity, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A.","family":"McGowan","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University, Stanford, CA, 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Schmidt-K\u00fcntzel","sequence":"additional","affiliation":[{"name":"Laboratory of Genomic Diversity, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA."},{"name":"Cheetah Conservation Fund, Post Office Box 1755, Otjiwarongo, Namibia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melody E.","family":"Roelke","sequence":"additional","affiliation":[{"name":"Laboratory of Genomic Diversity, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA."},{"name":"SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pino","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Florida International University, Miami, FL 33199, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Pontius","sequence":"additional","affiliation":[{"name":"Laboratory of Genomic Diversity, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA."},{"name":"SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Cooper","sequence":"additional","affiliation":[{"name":"HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermogenes","family":"Manuel","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University, Stanford, CA, 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Center for Conservation and Research of Endangered Wildlife, Cincinnati Zoo &amp; Botanical Garden, Cincinnati, OH 45220, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Marker","sequence":"additional","affiliation":[{"name":"Cheetah Conservation Fund, Post Office Box 1755, Otjiwarongo, Namibia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy K.","family":"Harper","sequence":"additional","affiliation":[{"name":"Veterinary Genetics Laboratory, Faculty of Veterinary Science Onderstepoort, University of Pretoria, Pretoria, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"van Dyk","sequence":"additional","affiliation":[{"name":"The Ann van Dyk Cheetah Centre, De Wildt, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bisong","family":"Yue","sequence":"additional","affiliation":[{"name":"Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife, College of Life Sciences, Sichuan University, Sichuan 610064, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Mullikin","sequence":"additional","affiliation":[{"name":"Comparative Genomics Unit, National Human Genome Research Institute, National Institutes of Health, Rockville, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley C.","family":"Warren","sequence":"additional","affiliation":[{"name":"The Genome Center, Washington University in St. Louis, St. Louis, MO 63108, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Eizirik","sequence":"additional","affiliation":[{"name":"Faculdade de Bioci\u00eancias, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil."},{"name":"Instituto Pr\u00f3-Carn\u00edvoros, Atibaia, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Kos","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Florida International University, Miami, FL 33199, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Laboratory of Genomic Diversity, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Barsh","sequence":"additional","affiliation":[{"name":"HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA."},{"name":"Department of Genetics, Stanford University, Stanford, CA, 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Menotti-Raymond","sequence":"additional","affiliation":[{"name":"Laboratory of Genomic Diversity, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/oxfordjournals.jhered.a110438","article-title":"Tabby pattern alleles of the domestic cat","volume":"79","author":"Lomax T. 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