{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:44:16Z","timestamp":1791477856151,"version":"4.3.4"},"reference-count":102,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6123","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Prevention or Repair<\/jats:title>\n          <jats:p>\n            Neural tube defects, such as spina bifida, remain remarkably common, despite widespread efforts to prevent them through supplementing maternal diets with folic acid. Surgery early in development has seen some success, but problems often remain.\n            <jats:bold>\n              Wallingford\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.1222002\">10.1126\/science.1222002<\/jats:related-article>\n            ) review normal and abnormal neural tube development and suggest that discovering the genetic risk factors for these serious birth defects could provide ways to prevent and treat neural tube defects.\n          <\/jats:p>","DOI":"10.1126\/science.1222002","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T20:46:33Z","timestamp":1362084393000},"source":"Crossref","is-referenced-by-count":416,"title":["The Continuing Challenge of Understanding, Preventing, and Treating Neural Tube Defects"],"prefix":"10.1126","volume":"339","author":[{"given":"John B.","family":"Wallingford","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee A.","family":"Niswander","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Finnell","sequence":"additional","affiliation":[{"name":"Dell Pediatric Research Institute, Department of Nutritional Sciences and Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78723, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1986"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014379"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20248"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20230"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1227-7"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2643"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30054"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1144"},{"key":"e_1_3_1_10_2","first-page":"1","article-title":"Neural tube defect surveillance and folic acid intervention\u2014Texas-Mexico border, 1993-1998","volume":"49","author":"Centers for Disease Control and Prevention (CDC)","year":"2000","unstructured":"Centers for Disease Control and Prevention (CDC), Neural tube defect surveillance and folic acid intervention\u2014Texas-Mexico border, 1993-1998. 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