{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:27:51Z","timestamp":1791224871305,"version":"4.1.0"},"reference-count":35,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6095","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,8,10]]},"abstract":"<jats:title>Current on Demand<\/jats:title>\n          <jats:p>\n            Deep brain electrical stimulation can be a successful therapy in Parkinson's disease, in depression, and in several other psychiatric diseases, especially in drug-resistant cases. Unfortunately, chronic, continuous stimulation is associated with multiple side effects. This could be alleviated by delivering the electrical perturbation only when it is necessary, using closed-loop stimulation. Such an approach is essential for epilepsy, where seizures occur very rarely but with serious consequences. In a rat model for epilepsy,\n            <jats:bold>\n              Ber\u00e9nyi\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"735\" related-article-type=\"in-this-issue\" vol=\"337\" xlink:href=\"10.1126\/science.1223154\">735<\/jats:related-article>\n            ) prevented seizures by transcranial electrical stimulation using a closed-loop system. Transcranial electrical stimulation was highly effective and reduced seizure duration, on average, by 60 %.\n          <\/jats:p>","DOI":"10.1126\/science.1223154","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T19:11:01Z","timestamp":1344539461000},"page":"735-737","source":"Crossref","is-referenced-by-count":411,"title":["Closed-Loop Control of Epilepsy by Transcranial Electrical Stimulation"],"prefix":"10.1126","volume":"337","author":[{"given":"Antal","family":"Ber\u00e9nyi","sequence":"first","affiliation":[{"name":"Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA."},{"name":"Neuroscience Institute, School of Medicine, New York University, New York, NY 10016, USA."},{"name":"Department of Physiology, University of Szeged, Szeged, H-6720, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Belluscio","sequence":"additional","affiliation":[{"name":"Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dun","family":"Mao","sequence":"additional","affiliation":[{"name":"Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Buzs\u00e1ki","sequence":"additional","affiliation":[{"name":"Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA."},{"name":"Neuroscience Institute, School of Medicine, New York University, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.05.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.02.014"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.29.051605.112824"},{"key":"e_1_3_2_5_2","first-page":"7560","article-title":"Transcranial focal stimulation via concentric ring electrodes reduced power of pentylenetetrazole-induced seizure activity in rat electroencephalogram","volume":"2011","author":"Makeyev O.","year":"2011","unstructured":"Makeyev O., Liu X., Koka K., Kay S. M., Besio W. G., Transcranial focal stimulation via concentric ring electrodes reduced power of pentylenetetrazole-induced seizure activity in rat electroencephalogram. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2011, 7560 (2011).22256088","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.24901.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/370615a0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2384"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2011.01.002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.08.023"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.07.016"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182302056"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02536.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22621"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.06.007"},{"key":"e_1_3_2_16_2","first-page":"37","article-title":"Genetic absence epilepsy in rats from Strasbourg\u2014a review","volume":"35","author":"Marescaux C.","year":"1992","unstructured":"Marescaux C., Vergnes M., Depaulis A., Genetic absence epilepsy in rats from Strasbourg\u2014a review. J. Neural Transm. Suppl. 35, 37 (1992).1512594","journal-title":"J. Neural Transm. Suppl."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.06.005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2009.01.003"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5252-09.2010"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.01.024"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05278"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1523\/JNEUROSCI.17-17-06783.1997","article-title":"Cellular-synaptic generation of sleep spindles, spike-and-wave discharges, and evoked thalamocortical responses in the neocortex of the rat","volume":"17","author":"Kandel A.","year":"1997","unstructured":"Kandel A., Buzs\u00e1ki G., Cellular-synaptic generation of sleep spindles, spike-and-wave discharges, and evoked thalamocortical responses in the neocortex of the rat. J. Neurosci. 17, 6783 (1997).9254689","journal-title":"J. Neurosci."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(81)90045-5"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.03.007"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2003.48202.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2011.2158586"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135241"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.05.004"},{"key":"e_1_3_2_30_2","first-page":"e3568","article-title":"Large-scale recording of neurons by movable silicon probes in behaving rodents","volume":"61","author":"Vandecasteele M.","year":"2012","unstructured":"Vandecasteele M., et al.., Large-scale recording of neurons by movable silicon probes in behaving rodents. J. Vis. Exp. 61, e3568 (2012).22415550","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00329-4"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.1.401"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3077"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2880"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3078"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235588"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-011-1009-3"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1223154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T15:34:15Z","timestamp":1704900855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1223154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,10]]},"references-count":35,"journal-issue":{"issue":"6095","published-print":{"date-parts":[[2012,8,10]]}},"alternative-id":["10.1126\/science.1223154"],"URL":"https:\/\/doi.org\/10.1126\/science.1223154","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,10]]}}}