{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:13:26Z","timestamp":1792113206930,"version":"4.4.0"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6093","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,7,27]]},"abstract":"<jats:title>Sarm-Assisted Suicide<\/jats:title>\n                  <jats:p>\n                    Neurodegenerative disease or nerve lesions cause axons and synapses to disintegrate through a process known as Wallerian degeneration, which may involve an active \u201caxon death program.\u201d\n                    <jats:bold>\n                      Osterloh\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"481\" related-article-type=\"in-this-issue\" vol=\"337\" xlink:href=\"10.1126\/science.1223899\">481<\/jats:related-article>\n                    , published online 7 June; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6093\" page=\"418\" related-article-type=\"in-this-issue\" vol=\"337\" xlink:href=\"10.1126\/science.1226150\">Yu and Luo<\/jats:related-article>\n                    <\/jats:bold>\n                    ) identify loss-of-function mutations in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    dSarm that are capable of blocking the degeneration of severed axons for the fly life span. Deletion of mouse Sarm1 provides similar protection to severed axons for weeks after injury, which suggests that Sarm is part of an ancient axonal death signaling cascade.\n                  <\/jats:p>","DOI":"10.1126\/science.1223899","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T23:12:35Z","timestamp":1339110755000},"page":"481-484","source":"Crossref","is-referenced-by-count":682,"title":["dSarm\/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway"],"prefix":"10.1126","volume":"337","author":[{"given":"Jeannette M.","family":"Osterloh","sequence":"first","affiliation":[{"name":"Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Brain Development and Repair, The Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Rooney","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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