{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:46:33Z","timestamp":1791323193093,"version":"4.3.1"},"reference-count":50,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6102","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,9,28]]},"abstract":"<jats:title>Keeping Cancer Cells At Bay<\/jats:title>\n                  <jats:p>\n                    Cancer cells are often aneuploid; that is, they have an abnormal number of chromosomes. But to what extent this contributes to the tumorigenic phenotype is not clear.\n                    <jats:bold>\n                      Senovilla\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1678\" related-article-type=\"in-this-issue\" vol=\"337\" xlink:href=\"10.1126\/science.1224922\">1678<\/jats:related-article>\n                    ; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6102\" page=\"1616\" related-article-type=\"in-this-issue\" vol=\"337\" xlink:href=\"10.1126\/science.1228464\">Zanetti and Mahadevan<\/jats:related-article>\n                    <\/jats:bold>\n                    ) found that tetraploidization of cancer cells can cause them to become immunogenic and thus aid in their clearance from the body by the immune system. Cells with excess chromosomes put stress on the endoplasmic reticulum, which leads to movement of the protein calreticulin to the cell surface. Calreticulin exposure in turn caused recognition of cancer cells in mice by the host immune system. Thus, the immune system appears to serve a protective role in eliminating hyperploid cells that must be overcome to allow unrestricted growth of cancer cells.\n                  <\/jats:p>","DOI":"10.1126\/science.1224922","type":"journal-article","created":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T13:49:15Z","timestamp":1349012955000},"page":"1678-1684","source":"Crossref","is-referenced-by-count":413,"title":["An Immunosurveillance Mechanism Controls Cancer Cell Ploidy"],"prefix":"10.1126","volume":"337","author":[{"given":"Laura","family":"Senovilla","sequence":"first","affiliation":[{"name":"INSERM, U848, Villejuif, France."},{"name":"Institut Gustave Roussy, Villejuif, France."},{"name":"Universit\u00e9 Paris Sud\/Paris 11, Facult\u00e9 de M\u00e9decine, Le Kremlin Bic\u00eatre, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilio","family":"Vitale","sequence":"additional","affiliation":[{"name":"INSERM, U848, Villejuif, 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