{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:13:09Z","timestamp":1792735989804,"version":"4.5.0"},"reference-count":25,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6110","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,11,23]]},"abstract":"<jats:title>Axing Autophagy<\/jats:title>\n                  <jats:p>\n                    When intracellular pathogens like\n                    <jats:italic>Legionella pneumophila<\/jats:italic>\n                    take up residence in mammalian host cells, they must combat the efforts of the host cell to attack them. Autophagy is a process by which cells digest their own constituents, often involved in response to starvation or pathogen attack.\n                    <jats:bold>\n                      Choy\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1072\" related-article-type=\"in-this-issue\" vol=\"338\" xlink:href=\"10.1126\/science.1227026\">1072<\/jats:related-article>\n                    , published online 25 October) now describe how\n                    <jats:italic>L. pneumophila<\/jats:italic>\n                    can inhibit the autophagy pathway in eukaryotic cells, and provide a detailed description of the biochemical mechanism. A\n                    <jats:italic>Legionella<\/jats:italic>\n                    effector protein, RavZ, acts as a very potent enzyme that specifically deconjugates a key autophagy protein, Atg8, from autophagosomal membranes, thus blocking autophagy.\n                  <\/jats:p>","DOI":"10.1126\/science.1227026","type":"journal-article","created":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T21:01:01Z","timestamp":1351285261000},"page":"1072-1076","source":"Crossref","is-referenced-by-count":480,"title":["The\n                    <i>Legionella<\/i>\n                    Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation"],"prefix":"10.1126","volume":"338","author":[{"given":"Augustine","family":"Choy","sequence":"first","affiliation":[{"name":"Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Dancourt","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Mugo","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara J.","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph R.","family":"Isberg","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Melia","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig R.","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, 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