{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:20:29Z","timestamp":1791825629906,"version":"4.3.4"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6148","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,8,23]]},"abstract":"<jats:title>Neural Crest Development<\/jats:title>\n          <jats:p>\n            The vertebrate neural crest is characterized by a migratory population of multipotent cells that spread out from the dorsal side of the neural tube. Many different cell types and tissues originate here, including cells of the peripheral nervous system, the adrenal medulla, melanocytes, and some skeletal cells. Dysregulation of neural crest cells can lead to defects in cell differentiation and the cell cycle, as well as to the formation of ectopic tissue, which can result in various human diseases.\n            <jats:bold>\n              Takahashi\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6148\" page=\"860\" related-article-type=\"in-this-issue\" vol=\"341\" xlink:href=\"10.1126\/science.1230717\">860<\/jats:related-article>\n            ) review the normal development of neural crest cells, highlighting important associations of this cell population with local environments to influence tissue interactions and function, and describe pathogenesis that results when developmental events go awry.\n          <\/jats:p>","DOI":"10.1126\/science.1230717","type":"journal-article","created":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T18:12:54Z","timestamp":1377195174000},"page":"860-863","source":"Crossref","is-referenced-by-count":125,"title":["Tissue Interactions in Neural Crest Cell Development and Disease"],"prefix":"10.1126","volume":"341","author":[{"given":"Yoshiko","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Zoology, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan."},{"name":"Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST), Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Sipp","sequence":"additional","affiliation":[{"name":"Center for Developmental Biology, RIKEN, 2-2-3 Minatojima Minamimachi, Chuo-ku, Kobe 650-0047, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Center for Developmental Biology, RIKEN, 2-2-3 Minatojima Minamimachi, Chuo-ku, Kobe 650-0047, Japan."},{"name":"Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","unstructured":"N. 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