{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:03:54Z","timestamp":1792760634582,"version":"4.5.0"},"reference-count":26,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6123","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Genetic Clues to Meningioma<\/jats:title>\n                  <jats:p>\n                    Meningiomas are the most common primary brain tumors in adults. Located within the layer of tissue covering the brain, these tumors are usually slow-growing and benign but can cause serious neurological complications. About half of these tumors have mutations in the\n                    <jats:italic>neurofibromin 2<\/jats:italic>\n                    gene (\n                    <jats:italic>NF2<\/jats:italic>\n                    ). To identify other genes that contribute to meningioma pathogenesis,\n                    <jats:bold>\n                      Clark\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6123\" page=\"1077\" related-article-type=\"in-this-issue\" vol=\"339\" xlink:href=\"10.1126\/science.1233009\">1077<\/jats:related-article>\n                    , published online 24 January) performed genome sequence analysis on 300 tumors. Meningiomas fell into two general classes: benign tumors located at the skull base\u2014which tend to harbor mutations in the\n                    <jats:italic>TRAF7, KLF4, AKT1<\/jats:italic>\n                    , and\n                    <jats:italic>SMO<\/jats:italic>\n                    genes\u2014and higher-grade tumors located in the cerebral and cerebellar hemispheres harbor mutations in\n                    <jats:italic>NF2.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1126\/science.1233009","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T21:38:41Z","timestamp":1359063521000},"page":"1077-1080","source":"Crossref","is-referenced-by-count":841,"title":["Genomic Analysis of Non-\n                    <i>NF2<\/i>\n                    Meningiomas Reveals Mutations in\n                    <i>TRAF7<\/i>\n                    ,\n                    <i>KLF4<\/i>\n                    ,\n                    <i>AKT1<\/i>\n                    , and\n                    <i>SMO<\/i>"],"prefix":"10.1126","volume":"339","author":[{"given":"Victoria E.","family":"Clark","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Zeynep","family":"Erson-Omay","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akdes","family":"Serin","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Cotney","sequence":"additional","affiliation":[{"name":"Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koray","family":"\u00d6zduman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Acibadem University School of Medicine, Istanbul \r34848, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timu\u00e7in","family":"Av\u015far","sequence":"additional","affiliation":[{"name":"Dr. Orhan \u00d6calgiray Molecular Biology-Biotechnology and Genetics Research \rCenter, Istanbul Technical University, Maslak 34469, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip B.","family":"Murray","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavian","family":"Henegariu","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saliha","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Moliterno","family":"G\u00fcnel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brain Tumor Center, Memorial Sloan-Kettering \rCancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geneive","family":"Carri\u00f3n-Grant","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baran","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Marmara University School of Medicine, Istanbul \r34854, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Grady","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahattin","family":"Tanr\u0131kulu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Marmara University School of Medicine, Istanbul \r34854, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Bak\u0131rc\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hande","family":"Kaymak\u00e7alan","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioinformatics, Bahcesehir University, Istanbul 34353, \rTurkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Okay","family":"Caglayan","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leman","family":"Sencar","sequence":"additional","affiliation":[{"name":"Departments 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Fatih","family":"Atik","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Marmara University School of Medicine, Istanbul \r34854, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u015far","family":"Bayri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Marmara University School of Medicine, Istanbul \r34854, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwen","family":"Bai","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis E.","family":"Kolb","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"Hebert","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Genetics, Yale Program in Brain Tumor Research, \rYale School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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